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Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity

Nature Genetics volume 8, pages 141–147 (1994)Cite this article

Abstract

Cardiac arrhythmias cause sudden death in 300,000 United States citizens every year. In this study, we describe two new loci for an inherited cardiac arrhythmia, long QT syndrome (LQT). In 1991 we reported linkage of LQT to chromosome 11 p15.5. In this study we demonstrate further linkage to D7S483 in nine families with a combined lod score of 19.41 and to D3S1100 in three families with a combined score of 6.72. These findings localize major LQT genes to chromosomes 7q35–36 and 3p21–24, respectively. Linkage to any known locus was excluded in three families indicating that additional heterogeneity exists. Proteins encoded by different LQT genes may interact to modulate cardiac repolarization and arrhythmia risk.

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Author information

Authors and Affiliations

  1. Division of Cardiology, University of Utah Health Science Center, Salt Lake City, Utah, 84112, USA

    Changan Jiang, Donald Atkinson, Igor Splawski, G. Michael Vincent & Mark T. Keating

  2. Department of Human Genetics, University of Utah Health Science Center, Salt Lake City, Utah, 84112, USA

    Changan Jiang, Donald Atkinson, Igor Splawski & Mark T. Keating

  3. Eccles Program in Human Molecular Biology and Genetics, University of Utah Health Science Center, Salt Lake City, Utah, 84112, USA

    Changan Jiang, Donald Atkinson, Igor Splawski & Mark T. Keating

  4. Department of Pediatrics, Baylor College of Medicine, Houston, Texas, 77030, USA

    Jeffrey A. Towbin & Hua Li

  5. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA

    Jeffrey A. Towbin

  6. Division of Cardiology, Department of Medicine, Wayne State University, Detroit, Michigan, 48235, USA

    Michael H. Lehmann

  7. Department of Medicine, LDS Hospital, Salt Lake City, Utah, 84037, USA

    Katherine Timothy & G. Michael Vincent

  8. Molecular Biology, Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte, North Carolina, 28203, USA

    R. Thomas Taggart

  9. Department of Cardiology, University of Pavia, 20122, Italy

    Peter J. Schwartz

  10. Department of Medicine, University of Rochester Medical Center, Rochester Medical Center, Rochester, New York, 14627, USA

    Arthur J. Moss

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  1. Changan Jiang
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Jiang, C., Atkinson, D., Towbin, J. et al. Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity. Nat Genet 8, 141–147 (1994). https://doi.org/10.1038/ng1094-141

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