Abstract
The burgeoning field of leukocyte trafficking has created new and exciting opportunities in the clinic. Trafficking signals are being defined that finely control the movement of distinct subsets of immune cells into and out of specific tissues. Because the accumulation of leukocytes in tissues contributes to a wide variety of diseases, these 'molecular codes' have provided new targets for inhibiting tissue-specific inflammation, which have been confirmed in the clinic. However, immune cell migration is also critically important for the delivery of protective immune responses to tissues. Thus, the challenge for the future will be to identify the trafficking molecules that will most specifically inhibit the key subsets of cells that drive disease processes without affecting the migration and function of leukocytes required for protective immunity.
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Acknowledgements
Supported by the National Institutes of Health (A.D.L. and U.H.v.A.), the Dana Foundation (A.D.L. and U.H.v.A.), the Mary K. Iacocca Faculty Fellowship (U.H.v.A.), the Roche Organ Transplant Research Foundation (A.D.L.) and the Israel Science Foundation and MAIN, the EU6 Program for Migration and Inflammation (R.A.).
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Supplementary information
Supplementary Table 1
Selectin and selectin ligands (PDF 55 kb)
Supplementary Table 2
Integrinsa and endothelial ligands involved in leukocyte rolling and arrest (PDF 73 kb)
Supplementary Table 3
Chemoatrractant receptors and their chemokine and lipid ligands implicated in adhesion and chemotaxis (PDF 76 kb)
Supplementary Table 4
Key diapedesis and extracellular matrix counter-receptors (PDF 73 kb)
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Luster, A., Alon, R. & von Andrian, U. Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol 6, 1182–1190 (2005). https://doi.org/10.1038/ni1275
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DOI: https://doi.org/10.1038/ni1275
