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Sudden Cardio Arrest: Oxidative stress irritates the heart

Nature Medicine volume 16, pages 648–649 (2010)Cite this article

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Sudden cardiac death (SCD) and cardiac arrhythmias remain a daunting public health problem. It is estimated that there are between 250,000 and 400,000 SCDs in the United States each year1, most of which occur in the setting of heart failure or as a complication of ischemic heart disease, such as after myocardial infarction. Oxidant stress is recognized to have a central role in the development and progression of myocardial dysfunction—but the molecular targets of reactive oxidative species (ROS) remain obscure. Furthermore, knowledge of how disorders of the reduction-oxidation balance contribute mechanistically to disorders of cardiac electrophysiology and the risk of arrhythmias continues to evolve.

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Figure 1: Myocardial stress upsets the balance between antioxidant defense systems and production of ROS.

Kimberly Caesar

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Authors and Affiliations

  1. Gordon F. Tomaselli and Andreas S. Barth are in the Division of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.,

    Gordon F Tomaselli & Andreas S Barth

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  1. Gordon F Tomaselli
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  2. Andreas S Barth
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Correspondence to Gordon F Tomaselli.

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The authors declare no competing financial interests.

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Tomaselli, G., Barth, A. Sudden Cardio Arrest: Oxidative stress irritates the heart. Nat Med 16, 648–649 (2010). https://doi.org/10.1038/nm0610-648

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