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Making new contacts: the mTOR network in metabolism and signalling crosstalk

Nature Reviews Molecular Cell Biology volume 15, pages 155–162 (2014)Cite this article

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Abstract

More than 20 years after its discovery, our understanding of target of rapamycin (TOR) signalling continues to grow. Recent global 'omics' studies have revealed physiological roles of mammalian TOR (mTOR) in protein, nucleotide and lipid synthesis. Furthermore, emerging evidence provides new insight into the control of mTOR by other pathways such as Hippo, WNT and Notch signalling. Together, this progress has expanded the list of downstream effectors and upstream regulators of mTOR signalling.

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Figure 1: Upstream of mTOR: classical and non-classical inputs.
Figure 2: mTOR controls metabolism.

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Acknowledgements

The authors acknowledge support from the Louis-Jeantet Foundation, the Swiss National Science Foundation and the Canton of Basel.

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  1. Biozentrum, University of Basel, Basel, 4056, Switzerland

    Mitsugu Shimobayashi & Michael N. Hall

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  1. Mitsugu Shimobayashi
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Correspondence to Michael N. Hall.

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Shimobayashi, M., Hall, M. Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat Rev Mol Cell Biol 15, 155–162 (2014). https://doi.org/10.1038/nrm3757

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