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Yeast and apoptosis

Nature Reviews Molecular Cell Biology volume 3, pages 453–459 (2002)Cite this article

Abstract

Even though yeast lack much of the molecular machinery that is responsible for apoptosis in metazoans, they can be a powerful tool in apoptosis research. The ectopic expression of several animal apoptosis proteins in yeast can help us to discover new genes — and chemical compounds — that modulate the cell-death pathways of higher eukaryotes.

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Figure 1: Caspase-dependent and -independent pathways of cell death in mammalian cells.

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Acknowledgements

We thank R. Cornell for manuscript preparation and the National Institutes of Health for generous support.

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Authors and Affiliations

  1. The Burnham Institute, 10901 N. Torrey Pines Rd, La Jolla, 92037, California, USA

    Can Jin & John C. Reed

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  1. Can Jin
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Correspondence to John C. Reed.

Related links

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DATABASES

Interpro

BIR

LocusLink

AIF

Bak

Bax

Bcl-XL

Bid

Flip

TUCAN

<i>Saccharomyces</i> Genome Database

Cdc48

Swiss-Prot

Annexin V

Apaf-1

Bar

Bcl-2

BI-1

caspase 3

caspase-9

caspase-10

catalase

CrmA

Endonuclease G

GFP

LacZ

Omi

pp60 Src

Smac

STAT-3

SOD

Wormbase

CED-4

CED-9

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Jin, C., Reed, J. Yeast and apoptosis. Nat Rev Mol Cell Biol 3, 453–459 (2002). https://doi.org/10.1038/nrm832

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