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Evolution of ageing

Nature volume 270, pages 301–304 (1977)Cite this article

Abstract

An evolutionary view of ageing suggests that mortality may be due to an energy-saving strategy of reduced error regulation in somatic cells. This supports Orgel's ‘error catastrophe’ hypothesis and offers a new basis for the study of normal and abnormal ageing syndromes and of apparently immortal transformed cell lines.

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References

  1. Weismann, A. in Weismann on Heredity (eds Poulton, E. B., Schönland, S. & Shipley, A. E.) 2nd edn, 23–42 (Oxford University Press, 1891).

    Google Scholar 

  2. Orgel, L. E. Proc. natn. Acad. Sci. U.S.A. 49, 517–521 (1963).

    Article  ADS  CAS  Google Scholar 

  3. Orgel, L. E. Proc. natn. Acad. Sci. U.S.A. 67, 1476 (1970).

    Article  ADS  CAS  Google Scholar 

  4. Hoffman, G. W. J. molec. Biol. 86, 349–362 (1974).

    Article  Google Scholar 

  5. Kirkwood, T. B. L. & Holliday, R. J. molec. Biol. 97, 257–265 (1975).

    Article  CAS  Google Scholar 

  6. Hayflick, L. & Moorhead, P. S. Expl Cell Res. 25, 585–621 (1961).

    Article  CAS  Google Scholar 

  7. Littlefield, J. W. in Variation, Senescence and Neoplasia in Cultured Somatic Cells, 62–64 (Harvard University Press, Cambridge, Massachusetts, 1976).

    Google Scholar 

  8. Martin, G., Sprague, C. & Epstein, C. Lab. Invest. 23, 86–92 (1970).

    CAS  Google Scholar 

  9. Kirkwood, T. B. L. & Holliday, R. J. theor. Biol. 53, 481–496 (1975).

    Article  CAS  Google Scholar 

  10. Holliday, R., Huschtscha, L. I., Tarrant, G. M. & Kirkwood, T. B. L. Science (in the press).

  11. Holliday, R. & Tarrant, G. M. Nature 238, 26–30 (1972).

    Article  ADS  CAS  Google Scholar 

  12. Linn, S., Kairis, M. & Holliday, R. Proc. natn. Acad. Sci. U.S.A. 73, 2818–2822 (1976).

    Article  ADS  CAS  Google Scholar 

  13. Dawkins, R. in The Selfish Gene 13–21 (Oxford University Press, 1976).

    Google Scholar 

  14. Hopfield, J. J. Proc. natn. Acad. Sci. U.S.A. 71, 4135–4139 (1974).

    Article  ADS  CAS  Google Scholar 

  15. Holliday, R. Fedn Proc. 34, 51–55 (1975).

    CAS  Google Scholar 

  16. Maynard Smith, J. & Price, G. R. Nature 246, 15–18 (1973).

    Article  Google Scholar 

  17. Medawar, P. B. An Unsolved Problem in Biology (H. K. Lewis, London, 1952).

    Google Scholar 

Download references

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Authors and Affiliations

  1. National Institute for Biological Standards and Control, Holly Hill, London, NW3 6RB

    T. B. L. Kirkwood

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  1. T. B. L. Kirkwood
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Kirkwood, T. Evolution of ageing. Nature 270, 301–304 (1977). https://doi.org/10.1038/270301a0

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