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Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein

Nature volume 377, pages 695–701 (1995)Cite this article

Abstract

The gene encoding p120-rasGAP, a negative regulator of Ras, has been disrupted in mice. This Gap mutation affects the ability of endothelial cells to organize into a highly vascularized network and results in extensive neuronal cell death. Mutations in the Gap and Nfl genes have a synergistic effect, such that embryos homozygous for mutations in both genes show an exacerbated Gap phenotype. Thus rasGAP and neurofibromin act together to regulate Ras activity during embryonic development.

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Authors and Affiliations

  1. Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada

    Mark Henkemeyer, Derrick J. Rossi, Douglas P. Holmyard, Mira C. Puri, Geraldine Mbamalu, Kendraprasad Harpal & Tony Pawson

  2. Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada

    Derrick J. Rossi, Mira C. Puri & Tony Pawson

  3. Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    T. Shane Shih & Tyler Jacks

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Henkemeyer, M., Rossi, D., Holmyard, D. et al. Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein. Nature 377, 695–701 (1995). https://doi.org/10.1038/377695a0

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