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What is flux balance analysis?

Nature Biotechnology volume 28, pages 245–248 (2010)Cite this article

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Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network. This primer covers the theoretical basis of the approach, several practical examples and a software toolbox for performing the calculations.

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Figure 1: The conceptual basis of constraint-based modeling.
Figure 2: Formulation of an FBA problem.

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Acknowledgements

This work was supported by National Institutes of Health grant no. R01 GM057089.

Author information

Authors and Affiliations

  1. Jeffrey D. Orth and Bernhard Ø. Palsson are at the University of California San Diego, La Jolla, California, USA.,

    Jeffrey D Orth & Bernhard Ø Palsson

  2. Ines Thiele is at the University of Iceland, Reykjavik, Iceland.,

    Ines Thiele

Authors
  1. Jeffrey D Orth
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  2. Ines Thiele
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  3. Bernhard Ø Palsson
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Corresponding author

Correspondence to Bernhard Ø Palsson.

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Orth, J., Thiele, I. & Palsson, B. What is flux balance analysis?. Nat Biotechnol 28, 245–248 (2010). https://doi.org/10.1038/nbt.1614

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