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Cell migration

EMT promotes contact inhibition of locomotion

Nature Reviews Molecular Cell Biology volume 16, page 518 (2015)Cite this article

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cells seem to acquire the ability to undergo CIL during developmental EMT

Neural crest cells from Xenopus laevis undergo CIL, and the authors asked whether their ability to do so is intrinsic or is acquired during development. They looked at cell populations before (premigratory neural crest (Premig-NC) cells) and after (migratory neural crest (Mig-NC) cells) EMT had taken place and observed that 80% of collisions between cultured Mig-NC cells showed CIL compared with only 40% of such collisions in Premig-NC cells. Furthermore, cell mixing in cultures was higher for Premig-NC cells, most of which formed stable contacts on collision and thus could not disperse, whereas Mig-NC cells underwent dispersion, which requires EMT. Thus, cells seem to acquire the ability to undergo CIL during developmental EMT.

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References

  1. Scarpa, E. et al. Cadherin switch during EMT in neural crest cells leads to contact inhibition of locomotion via repolarization of forces. Dev. Cell http://dx.doi.org/10.1016/j.devcel.2015.06.012 (2015)

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  1. Katharine H. Wrighton
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Lamouille, S., Xu, J. & Derynck, R. Molecular mechanisms of epithelial–mesenchymal transition. Nat. Rev. Mol. Cell Biol. 15, 178–196 (2014)

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Wrighton, K. EMT promotes contact inhibition of locomotion. Nat Rev Mol Cell Biol 16, 518 (2015). https://doi.org/10.1038/nrm4045

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