Processing body autoantibodies reconsidered

  1. Donald B. Bloch1,3,6,
  2. Tod Gulick1,4,6,
  3. Kenneth D. Bloch1,2,5,6, and
  4. Wei-Hong Yang1,3,6
  1. Departments of 1Medicine
  2. 2Anesthesia and Critical Care
  3. 3Center for Immunology and Inflammatory Diseases
  4. 4Diabetes Research Laboratory
  5. 5Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA
  6. 6Harvard Medical School, Boston, Massachusetts, 02115, USA

Abstract

Processing bodies (P-bodies) are cellular structures that have critical roles in mRNA degradation and post-transcriptional gene silencing. Some patients with autoimmune disease have high titer antibodies directed against P-bodies, and certain sera have been used as markers for the GW182 component of these structures. This study shows that available reference sera are unreliable markers for GW182 because the sera contain antibodies directed against Ge-1, a second P-body autoantigen.

Keywords

Footnotes

  • Reprint requests to: Donald B. Bloch, Massachusetts General Hospital-East; CNY 8302, 149 13th Street, Charlestown, MA 02129, USA; e-mail: bloch{at}helix.mgh.harvard.edu; fax: (617) 726-5651.

  • Article published online ahead of print. Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.17406.

    • Received January 30, 2006.
    • Accepted February 7, 2006.
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  1. Published in Advance March 23, 2006, doi: 10.1261/rna.17406 RNA 12: 707-709 Copyright © 2006 RNA Society

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