Permeabilization of the mitochondria usually leads to caspase activation and apoptosis. In the absence of caspase activation, these same mitochondrial changes can also lead to cell death. A recent study suggests that when good mitochondria go bad, the activation of both glycolysis and autophagy may permit cellular survival.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
206,07 € per year
only 17,17 € per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Colell, A. et al. Cell 129, 983–997 (2007).
Cramer, T. et al. Cell 112, 645–657 (2003).
Sirover, M. A. J. Cell. Biochem. 95, 45–52 (2005).
Chuang, D. M., Hough, C. & Senatorov, V. V. Annu. Rev. Pharmacol. Toxicol. 45, 269–290 (2005).
Hara, M.R. et al. Nature Cell Biol. 7, 665–674 (2005).
Gozuacik, D. & Kimchi, A. Curr. Top. Dev. Biol. 78, 217–245 (2007).
Kuma, A. et al. Nature 432, 1032–1036 (2004).
Kondoh, H. et al. Cancer Res. 65, 177–185 (2005).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Song, S., Finkel, T. GAPDH and the search for alternative energy. Nat Cell Biol 9, 869–870 (2007). https://doi.org/10.1038/ncb0807-869
Issue Date:
DOI: https://doi.org/10.1038/ncb0807-869
