APUD cell: Difference between revisions

'''APUD cells (DNES cells)''' constitute a group of apparently unrelated [[endocrine cell]]s, which were named by the [[scientist]] [[A.G.E. Pearse]], who developed the APUD concept in the early 1960s based on [[calcitonin]]-secreting parafollicular C cells of dog [[thyroid]].<ref>{{Cite journal |last=Boyd |first=C. A. R. |date=March 2001 |title=Amine uptake and peptide hormone secretion: APUD cells in a new landscape |journal=The Journal of Physiology |language=en |volume=531 |issue=3 |pages=581 |doi=10.1111/j.1469-7793.2001.0581h.x |issn=0022-3751 |pmc=2278499 |pmid=11251039}}</ref> These cells share the common function of secreting a low molecular weight [[peptide hormone|polypeptide hormone]]. There are several different types which secrete the hormones [[secretin]], [[cholecystokinin]] and several others. The name is derived from an [[acronym]], referring to the following:<ref>{{cite journal |author=Welbourn RB |title=Current status of the apudomas |journal=Ann. Surg. |volume=185 |issue=1 |pages=1–12 |date=January 1977 |pmid=12724 |pmc=1396259 |doi=10.1097/00000658-197701000-00001}} </ref><ref name=":0">{{cite journal | author = Pearse, A.G.|title = The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept | journal = J. Histochem. Cytochem. | volume = 17 | issue = 5 | year = 1969 | pages = 303–13 | pmid = 4143745 | doi=10.1177/17.5.303|s2cid = 8240028 | doi-access = free }}</ref>

==== Cells in APUD system ====

# ''Adenohypophysis''

# Neurons of ''Hypothalamus''

# '''Chief Cells''' of ''Parathyroid''

# '''''Adrenal Medullary''''' Cells

# '''Glomus''' cells in ''Carotid Body''

# '''Melanocytes'''[[Melanocyte]]s of ''Skin''

# Cells of ''Pineal Gland''

# '''[[Renin''']] producing cells in ''Kidney''the [[kidney]]