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Caspase 3 has been shown to [[Protein-protein interaction|interact]] with:
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* [[Caspase 8|CASP8]] <ref name="pmid11832478">{{cite journal | vauthors = Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES | title = Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria | journal = The Journal of Biological Chemistry | volume = 277 | issue = 16 | pages = 13430–7 | date = April 2002 | pmid = 11832478 | doi = 10.1074/jbc.M108029200 }}</ref><ref name="pmid8962078">{{cite journal | vauthors = Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G, Alnemri ES | title = Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 25 | pages = 14486–91 | date = December 1996 | pmid = 8962078 | pmc = 26159 | doi = 10.1073/pnas.93.25.14486 }}</ref>
* [[NMT2]]<ref>{{Cite journal | last1 = Selvakumar | first1 = P. | last2 = Sharma | first2 = RK. | title = Role of calpain and caspase system in the regulation of N-myristoyltransferase in human colon cancer (Review). | journal = Int J Mol Med | volume = 19 | issue = 5 | pages = 823–7 |date=May 2007 | doi = 10.3892/ijmm.19.5.823| PMID = 17390089 }}</ref>
* [[CFLAR]] <ref name="pmid9208847">{{cite journal | vauthors = Shu HB, Halpin DR, Goeddel DV | title = Casper is a FADD- and caspase-related inducer of apoptosis | journal = Immunity | volume = 6 | issue = 6 | pages = 751–63 | date = June 1997 | pmid = 9208847 | doi = 10.1016/S1074-7613(00)80450-1 }}</ref><ref name="pmid9326610">{{cite journal | vauthors = Han DK, Chaudhary PM, Wright ME, Friedman C, Trask BJ, Riedel RT, Baskin DG, Schwartz SM, Hood L | title = MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 21 | pages = 11333–8 | date = October 1997 | pmid = 9326610 | pmc = 23459 | doi = 10.1073/pnas.94.21.11333 }}</ref>
* [[Deleted in Colorectal Cancer|DCC]] <ref name="pmid11248093">{{cite journal | vauthors = Forcet C, Ye X, Granger L, Corset V, Shin H, Bredesen DE, Mehlen P | title = The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 6 | pages = 3416–21 | date = March 2001 | pmid = 11248093 | pmc = 30668 | doi = 10.1073/pnas.051378298 }}</ref>
* [[GroEL]] <ref name="pmid10205158">{{cite journal | vauthors = Samali A, Cai J, Zhivotovsky B, Jones DP, Orrenius S | title = Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells | journal = The EMBO Journal | volume = 18 | issue = 8 | pages = 2040–8 | date = April 1999 | pmid = 10205158 | pmc = 1171288 | doi = 10.1093/emboj/18.8.2040 }}</ref><ref name="pmid10205159">{{cite journal | vauthors = Xanthoudakis S, Roy S, Rasper D, Hennessey T, Aubin Y, Cassady R, Tawa P, Ruel R, Rosen A, Nicholson DW | title = Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis | journal = The EMBO Journal | volume = 18 | issue = 8 | pages = 2049–56 | date = April 1999 | pmid = 10205159 | pmc = 1171289 | doi = 10.1093/emboj/18.8.2049 }}</ref>
* [[HCLS1]] <ref name="pmid11988074">{{cite journal | vauthors = Ruzzene M, Penzo D, Pinna LA | title = Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells | journal = The Biochemical Journal | volume = 364 | issue = Pt 1 | pages = 41–7 | date = May 2002 | pmid = 11988074 | pmc = 1222543 | doi = 10.1042/bj3640041}}</ref><ref name="pmid11689006">{{cite journal | vauthors = Chen YR, Kori R, John B, Tan TH | title = Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis | journal = Biochemical and Biophysical Research Communications | volume = 288 | issue = 4 | pages = 981–9 | date = November 2001 | pmid = 11689006 | doi = 10.1006/bbrc.2001.5862 }}</ref>
* [[Survivin]] <ref name="pmid9850056">{{cite journal | vauthors = Tamm I, Wang Y, Sausville E, Scudiero DA, Vigna N, Oltersdorf T, Reed JC | title = IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs | journal = Cancer Research | volume = 58 | issue = 23 | pages = 5315–20 | date = December 1998 | pmid = 9850056 | doi = }}</ref><ref name="pmid11170436">{{cite journal | vauthors = Shin S, Sung BJ, Cho YS, Kim HJ, Ha NC, Hwang JI, Chung CW, Jung YK, Oh BH | title = An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7 | journal = Biochemistry | volume = 40 | issue = 4 | pages = 1117–23 | date = January 2001 | pmid = 11170436 | doi = 10.1021/bi001603q }}</ref>
* [[TRAF3]] <ref name="pmid11261798">{{cite journal | vauthors = Lee ZH, Lee SE, Kwack K, Yeo W, Lee TH, Bae SS, Suh PG, Kim HH | title = Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells | journal = Journal of Leukocyte Biology | volume = 69 | issue = 3 | pages = 490–6 | date = March 2001 | pmid = 11261798 | doi = }}</ref><ref name="pmid11098060">{{cite journal | vauthors = Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa S, Stennicke HR, Salvesen GS, Reed JC | title = TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis | journal = The Journal of Biological Chemistry | volume = 276 | issue = 11 | pages = 8087–93 | date = March 2001 | pmid = 11098060 | doi = 10.1074/jbc.M009450200 }}</ref>
* [[XIAP]] <ref name="pmid11447297">{{cite journal | vauthors = Suzuki Y, Nakabayashi Y, Takahashi R | title = Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 15 | pages = 8662–7 | date = July 2001 | pmid = 11447297 | pmc = 37492 | doi = 10.1073/pnas.161506698 }}</ref><ref name="pmid11927604">{{cite journal | vauthors = Silke J, Hawkins CJ, Ekert PG, Chew J, Day CL, Pakusch M, Verhagen AM, Vaux DL | title = The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites | journal = The Journal of Cell Biology | volume = 157 | issue = 1 | pages = 115–24 | date = April 2002 | pmid = 11927604 | pmc = 2173256 | doi = 10.1083/jcb.200108085 }}</ref><ref name="pmid11257232">{{cite journal | vauthors = Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS | title = Structural basis for the inhibition of caspase-3 by XIAP | journal = Cell | volume = 104 | issue = 5 | pages = 791–800 | date = March 2001 | pmid = 11257232 | doi = 10.1016/S0092-8674(01)00274-4 }}</ref><ref name="pmid9384571">{{cite journal | vauthors = Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC | title = The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases | journal = The EMBO Journal | volume = 16 | issue = 23 | pages = 6914–25 | date = December 1997 | pmid = 9384571 | pmc = 1170295 | doi = 10.1093/emboj/16.23.6914 }}</ref><ref name="pmid9230442">{{cite journal | vauthors = Deveraux QL, Takahashi R, Salvesen GS, Reed JC | title = X-linked IAP is a direct inhibitor of cell-death proteases | journal = Nature | volume = 388 | issue = 6639 | pages = 300–4 | date = July 1997 | pmid = 9230442 | doi = 10.1038/40901 }}</ref><ref name="pmid11359776">{{cite journal | vauthors = Suzuki Y, Nakabayashi Y, Nakata K, Reed JC, Takahashi R | title = X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes | journal = The Journal of Biological Chemistry | volume = 276 | issue = 29 | pages = 27058–63 | date = July 2001 | pmid = 11359776 | doi = 10.1074/jbc.M102415200 }}</ref>
* [[NFE2L2]] <ref name="pmid10510468">{{cite journal | vauthors = Ohtsubo T, Kamada S, Mikami T, Murakami H, Tsujimoto Y | title = Identification of NRF2, a member of the NF-E2 family of transcription factors, as a substrate for caspase-3(-like) proteases | journal = Cell Death and Differentiation | volume = 6 | issue = 9 | pages = 865–72 | date = September 1999 | pmid = 10510468 | doi = 10.1038/sj.cdd.4400566 }}</ref>{{Div col end}}
==Biological function==
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