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'''Caspase-3''' is a [[caspase]] protein that interacts with [[caspase-8]] and [[caspase-9]]. It is encoded by the ''CASP3'' gene. ''CASP3'' [[orthologs]] <ref name="OrthoMaM">{{cite web | title = OrthoMaM phylogenetic marker: CASP3 coding sequence | url = http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000164305_CASP3.xml }}</ref> have been identified in numerous [[mammal]]s for which complete genome data are available. Unique orthologs are also present in [[bird]]s, [[lizard]]s, [[lissamphibian]]s, and [[teleost]]s.
The '''CASP3''' [[protein]] is a member of the '''c'''ysteine-'''asp'''artic acid prote'''ase''' ([[caspase]]) family.<ref name="pmid8861900">{{cite journal | vauthors = Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J | title = Human ICE/CED-3 protease nomenclature | journal = Cell | volume = 87 | issue = 2 | pages = 171 | date = October 1996 | pmid = 8861900 | doi = 10.1016/S0092-8674(00)81334-3 }}</ref> Sequential activation of caspases plays a central role in the execution-phase of [[apoptosis|cell apoptosis]]. Caspases exist as inactive [[proenzyme]]s that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active [[enzyme]]. This protein cleaves and activates [[Caspase 6|caspases 6]] and [[Caspase 7|7]]; and the protein itself is processed and activated by caspases 8, 9, and [[Caspase 10|10]]. It is the predominant caspase involved in the cleavage of [[Early-onset Alzheimer's disease#APP .E2.80.93 Amyloid beta .28A4.29 precursor protein|amyloid-beta 4A precursor protein]], which is associated with neuronal death in [[Alzheimer's disease]].<ref>{{cite journal | vauthors = Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW | title = Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation | journal = Cell | volume = 97 | issue = 3 | pages = 395–406 | date = April 1999 | pmid = 10319819 | doi=10.1016/s0092-8674(00)80748-5}}</ref> Alternative splicing of this gene results in two transcript variants that encode the same protein.<ref>{{cite web | title = Entrez Gene: CASP3 caspase 3, apoptosis-related cysteine peptidase| url =
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