The first hotel to open its door was the Sol Cayo Santa Maria in Dec. 2001. All hotels in Cayo Santa María, currently 912 for a total of 68,119739 rooms, are owned by the Cuban group Gaviota. "CayoThe Santa« Cayos de Villa Clara María"» project is the construction of 10,000 rooms on the islands of Cayo Santa Maria, Cayo Ensenachos and Cayo Las Brujas.{{citation needed|date=AprilNovember 20142015}}
The hotels of the island are the "Melia Buenavista" (105 rooms), "Sol Cayo Santa María" (300 rooms), "Melia Cayo Santa María" 358 rooms), "Melia Las Dunas" (925 rooms), "Playa Cayo Santa María" (769 rooms), "GaviotaStarfish LaCayo Santa EstrellaMaria" (1,308 rooms), "Royalton Cayo Santa María" (122 rooms), "Memories Paraiso Azul Beach Resort" (1,386 rooms), Melia"Hotel BuenavistaCayo Santa María" (105846 rooms), "Warwick Cayo Santa Maria" (800 rooms), "Ocean Casa del Mar by H10" (800 rooms) and the "EurostarsValentin CayoPerla Santa MaríaBlanca" (8461,020 rooms). There is also one hotel in the neighbor island Cayo Ensenachos, the "Iberostars Ensenachos" (506 rooms).{{citation needed|date=AprilNovember 20142015}}
NewThere hotelsis areone undermore constructionhotel to be built in the eastern area of Cayo Santa Maria, called Playa Perla Blanca and Lagunas del Este. These hotels arenear the Valentin Perla Blanca, Warwickthe Cayo« Santa Maria and Ocean CasaLagunas del MarEste byV H10».{{citation needed|date=OctoberNovember 20142015}}
