Chlordecone: Difference between revisions

'''Chlordecone''', better known in the United States under the brand name '''Kepone''', is an [[organochlorine compound]] and a colourless solid. It is an obsolete [[insecticide]], related to [[Mirex]] and [[DDT]]. Its use was so disastrous that it is now prohibited in the western world, but only after many thousands of tonnes had been produced and used.<ref name=Ullmann2>Robert L. Metcalf "Insect Control" in ''Ullmann's Encyclopedia of Industrial Chemistry'' Wiley-VCH, Wienheim, 2002. {{DOIdoi|10.1002/14356007.a14_263}}</ref> Chlordecone is a known [[persistent organic pollutant]] (POP) that was banned globally by the [[Stockholm Convention on Persistent Organic Pollutants]] in 2009.<ref name="COP4, 2009 Press release">[http://chm.pops.int/Convention/Pressrelease/COP4Geneva8May2009/tabid/542/ Press Release – COP4 – Geneva, 8 May 2009: Governments unite to step-up reduction on global DDT reliance and add nine new chemicals under international treaty], 2009.</ref>

Chlordecone can accumulate in the liver and the distribution in the human body is regulated by binding of the pollutant or its metabolites to [[Lipoprotein|lipoproteins]] like [[Low-density lipoprotein|LDL]] and [[High-density lipoprotein|HDL]].<ref>{{cite journal |last1=Delannoy |first1=Matthieu |last2=Girardet |first2=Jean-Michel |last3=Djelti |first3=Fathia |last4=Yen |first4=Frances T. |last5=Cakir-Kiefer |first5=Céline |title=Affinity of chlordecone and chlordecol for human serum lipoproteins |journal=Environmental Toxicology and Pharmacology |date=1 November 2020 |volume=80 |pages=103486 |doi=10.1016/j.etap.2020.103486 |pmid=32891758 |s2cid=221523766 |url=https://hal.univ-lorraine.fr/hal-02925906/file/Delannoy%20et%20al.%20draft%20sent%20to%20editorial%20preprint%281%29.pdf }}</ref>