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Some scientific researchers argue that advances in artificial reproduction technology for the purposes of dog breeding can be helpful, but also have "detrimental impacts" when overused, overriding natural selection principles. These scientists call for a deeper understanding of natural selection, leading to a more naturalistic approach in dog breeding.<ref>{{cite journal|last=Vandeloo|first=John|title=Journal of Veterinary Behavior: Clinical Applications and Research Volume 4, Issue 6, November–December 2009, Pages 245 Cover image The importance of {{sic|inter|grating|nolink=yes|expected=integrating}} natural selection within a detector dog selective breeding model|journal=Journal of Veterinary Behavior: Clinical Applications and Research|date=2009|volume=4|issue=6}}</ref> It has been concluded that "findings imply that when selective breeding was done by humans, it squashed the snouts of certain dog breeds, it also morphed their brains."<ref>Jabr, Ferris. "Changing Minds: Has Selective Breeding Restructured Some Dog Brains?" Scientific American Global RSS. N.p., 13 Aug. 2010. Web. 10 Nov. 2014.
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Animal welfare groups such as the [[International Society for Animal Rights]] and [[PETA]] believe that dog breeding, even by licensed responsible breeders, contributes to the [[pet overpopulation]] problem. <ref> isaronline</ref>
==Inbreeding depression==
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