Flesh and Blood may refer to:
- Flesh and Blood (Roxy Music album), a 1980 album released by a British rock group Roxy Music
- Flesh and Blood (Poison album), a 1990 album released by an American heavy metal group Poison
- Flesh & Blood (film), a movie directed by Paul Verhoeven
- Flesh and Blood (novel), a novel by American author Jonathan Kellerman
- Flesh and Blood (John Harvey novel), a novel by British author John Harvey
- Flesh and Blood (Reay Tannahill novel), a novel by Scottish author Reay Tannahill
- Flesh and Blood (Hardy Boys novel), book #39 in the Hardy Boys Casefiles series
- "Flesh and Blood" (Stargate SG-1), an episode of the TV series Stargate SG-1
- "Flesh and Blood" (Solomon Burke song), a song by Solomon Burke from his 2002 album Don't Give Up On Me
- "Flesh and Blood" (Wilson Phillips song), a 1992 single by Wilson Phillips from their album Shadows & Light
- "Flesh 'N Blood" (Oingo Boingo song), a 1989 song by Oingo Boingo written for the movie Ghostbusters II