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{{short description|Gene formed by the combination of two independent genes}}
A '''fusion gene''' is a hybrid gene formed from two previously independent genes. It can occur as a result of [[Chromosomal translocation|translocation]], [[Deletion (genetics)|interstitial deletion]], or [[chromosomal inversion]]. Fusion genes have been found to be prevalent in all main types of human [[neoplasia]].<ref name=mitelman2007>{{cite journal | vauthors = Mitelman F, Johansson B, Mertens F | title = The impact of translocations and gene fusions on cancer causation | journal = Nature Reviews Cancer | volume = 7 | issue = 4 | pages = 233–45 | date = April 2007 | pmid = 17361217 | doi = 10.1038/nrc2091 | s2cid = 26093482 }}</ref> The identification of these fusion genes play a prominent role in being a diagnostic and prognostic marker.<ref>{{cite journal | vauthors = Prensner JR, Chinnaiyan AM | title = Oncogenic gene fusions in epithelial carcinomas | journal = Current Opinion in Genetics & Development | volume = 19 | issue = 1 | pages = 82–91 | date = February 2009 | pmid = 19233641 | pmc = 2676581 | doi = 10.1016/j.gde.2008.11.008 }}</ref>▼
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[[File:Gene Fusion Types.png|thumb|A schematic showing the ways a fusion gene can occur at a chromosomal level]]
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