MMP2: Difference between revisions

Altered expression and activity levels of MMPs have been strongly implicated in the progression and [[metastasis]] of many forms of cancer. Increased MMP-2 activity has also been linked with a poor [[prognosis]] in multiple forms of cancer including [[Colorectal cancer|colorectal]], [[melanoma]], [[breast cancer|breast]], [[lung cancer|lung]], [[Ovarian cancer|ovarian]], and [[prostate cancer|prostate]].<ref name=":0">{{vcite2 journal | vauthors = Björklund M, Koivunen E | title = Gelatinase-mediated migration and invasion of cancer cells | journal = Biochimica et Biophysica Acta | volume = 1755 | issue = 1 | pages = 37–69 | date = May 2005 | pmid = 15907591 | doi = 10.1016/j.bbcan.2005.03.001 }}</ref> Furthermore, changes in MMP-2 activity can come from alterations in levels of [[Transcription (genetics)|transcription]], MMP secretion, MMP activation, or MMP inhibition. MMP production in many cancers may be upregulated in surrounding [[Stroma (animal tissue)|stromal tissue]] rather than simply in the tumor lesion. For instance, Mook, et al. showed that MMP-2 mRNA levels are strikingly similar between metastatic and non-metastatic lesions in colorectal cancer, but metastatic cases are correlated with higher levels of MMP-2 mRNA in surrounding healthy tissue.<ref name="Mook_2004">{{vcite2 journal | vauthors = Mook OR, Frederiks WM, Van Noorden CJ | title = The role of gelatinases in colorectal cancer progression and metastasis | journal = Biochimica et Biophysica Acta | volume = 1705 | issue = 2 | pages = 69–89 | date = Dec 2004 | pmid = 15588763 | doi = 10.1016/j.bbcan.2004.09.006 }}</ref> For this reason, it is difficult to fully understand the complex role of MMPs in cancer progression.