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== Function ==
Proteins of the [[matrix metalloproteinase]] (MMP) family are involved in the breakdown of [[extracellular matrix]] (ECM) in normal physiological processes, such as [[embryonic development]], [[reproduction]], and tissue remodeling, as well as in disease processes, such as [[arthritis]] and [[metastasis]]. Most MMP's are secreted as inactive [[proprotein]]s which are activated when cleaved by extracellular [[proteinase]]s. This gene encodes an enzyme which degrades type IV [[collagen]], the major structural component of [[basement membrane]]s. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.<ref>{{cite web | title = Entrez Gene: MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4313| accessdate = }}</ref> The role of MMP2 in [[lymphangiogenesis]] was considered in a modelling and theoretical study.<ref>{{Cite journal|last=Wertheim|first=Kenneth Y.|last2=Roose|first2=Tiina|date=April 2017
== Activation ==
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