MMP2: Difference between revisions

Proteins of the [[matrix metalloproteinase]] (MMP) family are involved in the breakdown of [[extracellular matrix]] (ECM) in normal physiological processes, such as [[embryonic development]], [[reproduction]], and tissue remodeling, as well as in disease processes, such as [[arthritis]] and [[metastasis]]. Most MMP's are secreted as inactive [[proprotein]]s which are activated when cleaved by extracellular [[proteinase]]s. This gene encodes an enzyme which degrades type IV [[collagen]], the major structural component of [[basement membrane]]s. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.<ref>{{cite web | title = Entrez Gene: MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4313| accessdate = }}</ref> The role of MMP2 in [[lymphangiogenesis]] was considered in a modelling and theoretical study; MMP2 degrades [[Type I collagen|collagen I]] to switch on different patterning mechanisms for [[Vascular endothelial growth factor C|VEGFC]].<ref>{{Cite journal|last=Wertheim|first=Kenneth Y.|last2=Roose|first2=Tiina|date=April 2017|title=A Mathematical Model of Lymphangiogenesis in a Zebrafish Embryo|journal=Bulletin of Mathematical Biology|volume=79|issue=4|pages=693–737|doi=10.1007/s11538-017-0248-7|issn=1522-9602|pmc=5501200|pmid=28233173}}</ref><ref>{{Cite journal|last=Roose|first=Tiina|last2=Wertheim|first2=Kenneth Y.|date=2019-01-03|title=Can VEGFC Form Turing Patterns in the Zebrafish Embryo?|url=https://link.springer.com/article/10.1007/s11538-018-00560-2|journal=Bulletin of Mathematical Biology|language=en|pages=1–37|doi=10.1007/s11538-018-00560-2|issn=1522-9602}}</ref>