The song samples Melvin Bliss' "[[Synthetic Substitution]]" and [[The Jackson 5]]'s "[[ABC (The Jackson 5 song)|ABC]]". Its lyrics concern sexual infidelity, with "O.P.P." standing for "other people's puppiespussy" and "other people's penguinspenis". [[Treach]] told in an interview with ''[[New York Times]]'', "'O.P.P.' is about crazy messing with other people's petsgirls. Everybody knows about that, girls messing, guys messing, you know the bit. It goes on, so everybody could relate, the fellas and the girls, and it's got a hook for the party and everybody can crazy groove to it."<ref name="newyorktimes">Watrous, Peter (August 14, 1991). "The Pop Life". ''[[New York Times]]''.</ref>
