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Prokaryotic DNA replication is the process by which a [[prokaryote]] duplicates its entire [[genome]] into another copy that is passed on to daughter cells.<ref>{{cite web|title=What is DNA Replication?|url=http://www.yourgenome.org/facts/what-is-dna-replication|website=yourgenome.org|publisher=Wellcome Genome Campus|accessdate=24 February 2017}}</ref> Although it is often studied in the [[model organism]] ''[[E. coli]]'', other [[bacteria]] show many similarities.<ref name=":0">{{Cite journal|last=Wolański|first=Marcin|last2=Donczew|first2=Rafał|last3=Zawilak-Pawlik|first3=Anna|last4=Zakrzewska-Czerwińska|first4=Jolanta|date=2014-01-01|year=2014|title=oriC-encoded instructions for the initiation of bacterial chromosome replication|url=https://www.ncbi.nlm.nih.gov/pubmed/25610430|journal=Frontiers in Microbiology|volume=5|pages=735|doi=10.3389/fmicb.2014.00735|pmc=4285127|pmid=25610430|via=}}</ref> Replication is bi-directional and originates at a single [[origin of replication]] (OriC).<ref>{{Cite journal|last=Bird|first=R. E.|last2=Louarn|first2=J.|last3=Martuscelli|first3=J.|last4=Caro|first4=L.|date=1972-10-14|year=1972|title=Origin and sequence of chromosome replication in Escherichia coli|url=https://www.ncbi.nlm.nih.gov/pubmed/4563262|journal=Journal of Molecular Biology|volume=70|issue=3|pages=549–566|issn=0022-2836|pmid=4563262|via=}}</ref> It consists of three steps: Initation, elongation, and termination.<ref>{{Cite journal|last=Bussiere|first=Dirksen E.|last2=Bastia|first2=Deepak|date=1999-04-01|title=Termination of DNA replication of bacterial and plasmid chromosomes|url=http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2958.1999.01287.x/abstract|journal=Molecular Microbiology|language=en|volume=31|issue=6|pages=1611–1618|doi=10.1046/j.1365-2958.1999.01287.x|issn=1365-2958}}</ref>
==Initiation==
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