Talk:Methionine

Hi, I just edited the main page, sorry I should have asked first, I thought that some foods on the list of rich sources of Methionine were wrong - oranges have comparatively little Methionine as do most fruit and veg compared to nuts or meat. I've based this pre-dominately on this source - http://www.nutritiondata.com/nutrient-search.html (the menu can be used to look at sources of Methionine in the various food groups).

--134.225.163.117 16:19, 29 March 2006 (UTC)

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According to my biochemsitry text, the pKas for Methionine are 2.28 and 9.21, giving an isoelectric point of 5.745. Here, the pKas appear to be incorrect, and they do not give the correct IP of Met.

--Priss 05:06, 10 October 2005 (UTC)

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You know, even if methionine is incorporated into the N-terminal position of a newly synthesized protein, there is no guarantee that in the mature product, it is still the N-terminal amino acid. Some proteins and peptides (for example, insulin) are subjected to the actions of proteases before assuming their mature form. Some proteins have leader sequences that allow them to be transported to their place of action, and the leader sequence is cleaved once transport takes place. David M

Where I work, the people in another lab a few years were trying to label a protein by incorporating sulfur isotope labelled methionine. They tried and tried, and got nowhere... turned out the protein had no methionine. Malcolm Farmer

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"Together with tryptophan, it is the only amino acid needing three bases to encode (nucleotide codon AGT for methionine)."

This makes no sense to me, can someone explain.

Jedi Dan 18:32 Apr 23, 2003 (UTC)

I think I see what the writer intended... I've rewritten it to make it clearer. (I hope) 147.188.60.51

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Does methionine occur in positions other than the N-terminus?

Thanks, has_no_nick

Reply to self:

Yes, it occurs at other positions in some proteins.

I'll just add that on the page. Regards.

"Usually removed"?

Is there any evidence to have the phrase "usually removed by post-translational modification"? If so, can someone put that in. If not, then perhaps the wording shouldn't be as strong (how many proteins in how many species are known to have this phenomenon?).

SMILES

Currently the SMILES is

C(N)(C(O)O)CCSC

but shouldn't it be

C(N)(C(=O)O)CCSC

? I went ahead and change it but please revert if I'm missing something here. Cburnett 05:06, 19 April 2006 (UTC)

External link request

Hi. Will you put a link to my site on this page? like this: drugs-about.com/ing/methionine.html Drugs and Health Products containing Methionine

Thank you.

That website does not appear to meet criteria for inclusion because of its highly commercial content and purpose. Please see the guidelines for external links at WP:EL and WP:SPAM. Thanks for asking, though, which is a rarity. Deli nk 17:25, 27 September 2006 (UTC)

Moved from comments page

Hi, I would like to know information about SAMe (s-adenosyl-methionine) and in particular, claims that it can aid in recovery of depression. - 09:21, 29 March 2007 60.242.72.197 —The preceding unsigned comment was added by Tameeria (talk • contribs) 19:53, 28 April 2007 (UTC).

DL-methionine

DL-methionine should be mentioned in the article, as it is under this name that this chemical is added to foodstuffs. Badagnani 23:17, 5 August 2007 (UTC)

L-Methionine as wart removal?

I've had a Doctor prescribe this for me a couple of times to help recover from a wart.

Does anything have access to something more official to include as references to add this information to this article?

I found a couple of things from a google search:

http://talesfromthecrib.blogspot.com/2006/04/herbal-remedies-for-everyday-mom.html http://bodyodd.msnbc.msn.com/archive/2008/10/28/1603159.aspx?p=1

I also saw some abstracts on the topic:

http://www.ncbi.nlm.nih.gov/pubmed/5741494?dopt=Abstract http://linkinghub.elsevier.com/retrieve/pii/S0733863505701790

Can we gather enough information to include this in the article —Preceding unsigned comment added by Magicalspirits (talk • contribs) 22:45, 14 January 2009 (UTC)

Methionine restriction

Don't the Methionine restriction facts sound contradictory. What are the real results? —Preceding unsigned comment added by 78.190.134.130 (talk) 14:14, 6 December 2009 (UTC)

Is meat and fish forbidden by law of Lord Vegan ?

I read that fish and meat are very good source, but i get in front a table with only plant source. —Preceding unsigned comment added by 129.16.137.100 (talk) 18:09, 16 June 2010 (UTC)

contradictory statements about rice & beans.

The article is currently self-contradictory: We have this table:

Food                   g/100g
Beans, pinto, cooked 	0.117
Lentils, cooked 	0.077
Rice, brown, medium-grain, cooked 	0.052

which implies that both rice & beans have among the very lowest in methionine content (rice hitting rock-bottom in the list). Then we have a photo caption:

Rice and beans provides a complete protein, the methionine in the rice complementing the proteins in the beans.

I've removed the rice&beans photo, this seemed easiest, given that the table seems to be properly referenced. I hope someone can fix this. linas (talk) 00:44, 7 September 2010 (UTC)

methionine linked to age deterioration

two groups -- those with a BDNF gene that contained methionine, and those with a BDNF gene that did not contain methionine.

http://news.yahoo.com/aging-brains-decline-may-hinge-gene-130406334.html — Preceding unsigned comment added by 75.85.14.106 (talk) 09:32, 26 October 2011 (UTC)