Vortioxetine: Difference between revisions

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[[Sexual dysfunction]], such as [[decreased libido]], [[abnormal orgasm]], [[delayed ejaculation]], and [[erectile dysfunction]], are well-known side effects of SSRIs and [[serotonin–norepinephrine reuptake inhibitor]]s (SNRIs).<ref name="pmid25562777" /> In clinical trials, sexual dysfunction occurred more often with vortioxetine than with [[placebo]] and appeared to be dose-dependent.<ref name="pmid25562777" /><ref name="pmid25907797" /> The specific incidences{{verify spelling|date=September 2022|reason=''incidence'' is normally used only in the singular form, perhaps ''incidence'', ''incidents'', or ''instances'' was intended}}Incidence of treatment-emergent sexual dysfunction as measured with the [[Arizona Sexual Experience Scale]] (ASEX) were 14 to 20% for placebo and 16 to 34% for vortioxetine over a dosage range of 5 to 20&nbsp;mg/day.<ref name="pmid25562777" /><ref name="pmid25907797" /> The incidence of sexual dysfunction with vortioxetine was similar to that with the SNRI [[duloxetine]], which had an incidence of 26 to 28% at the used dosage of 60&nbsp;mg/day.<ref name="pmid25562777" /> However, treatment-emergent sexual dysfunction caused by a prior SSRI was better improved by switching to vortioxetine than by switching to the SSRI [[escitalopram]].<ref name="Trintellix FDA label" /> In another study, vortioxetine at a dosage of 10&nbsp;mg/day though not at 20&nbsp;mg/day produced less sexual dysfunction than the SSRI [[paroxetine]].<ref name="Trintellix FDA label" /> These findings suggest that although vortioxetine can still cause sexual dysfunction itself, it may cause somewhat less sexual dysfunction than SSRIs and might be a useful alternative option for people experiencing sexual dysfunction with these medications.<ref name="Trintellix FDA label" /><ref name="pmid29344340">{{cite journal | vauthors = Chokka PR, Hankey JR | title = Assessment and management of sexual dysfunction in the context of depression | journal = Ther Adv Psychopharmacol | volume = 8 | issue = 1 | pages = 13–23 | date = January 2018 | pmid = 29344340 | pmc = 5761906 | doi = 10.1177/2045125317720642 | url = }}</ref> The rates of voluntarily or spontaneously reported sexual dysfunction with vortioxetine are much lower than with the ASEX, ranging from <1 to 5% for vortioxetine versus <1 to 2% for placebo in clinical trials.<ref name="pmid25907797" /><ref name="pmid25562777" /><ref name="Trintellix FDA label" />

Vortioxetine was previously sold under the brand name Brintellix in the United States, but in May 2016, the US [[Food and Drug Administration]] (FDA) approved a name change to Trintellix in order to avoid confusion with the blood-thinning medication Brilinta ([[ticagrelor]]).<ref>{{Cite web|url=https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm498607.htm|title=Safety Alerts for Human Medical Products - Brintellix (vortioxetine): Drug Safety Communication - Brand Name Change to Trintellix, to Avoid Confusion With Antiplatelet Drug Brilinta (ticagrelor |publisher=U.S. [[Food and Drug Administration]] (FDA)|access-date=2 May 2016|url-status=dead|archive-url= https://web.archive.org/web/20160505122409/https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm498607.htm |archive-date=5 May 2016}}</ref> Other brand names include Torvox, Vantaxa, Voxigain, and Trivoxetin.<ref>{{cncite web|url=https://m.netmeds.com/generics/vortioxetine-10mg|title=Substitute Brands for Voxigain Tablet 10mg|website=Netmeds|access-date=June31 August 2024}}</ref>

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