C-myc internal ribosome entry site (IRES)

c-myc internal ribosome entry site (IRES)
c-myc internal ribosome entry site (IRES)
	Predicted secondary structure and sequence conservation of IRES_c-myc
Identifiers
Symbol	IRES_c-myc
Alt. Symbols	c-myc_IRES
Rfam	RF00216
Other data
RNA type	Cis-reg; IRES
Domain(s)	Eukaryota
GO	GO:0043022
SO	SO:0000243
PDB structures	PDBe

The c-myc internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of C-myc and allows cap-independent translation. The mammalian c-myc gene is a proto-oncogene which is required for cell proliferation, transformation and death. c-myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5' UTR thus bypassing the typical eukaryotic cap-dependent translation pathway.^[1]

References

^ Le Quesne JP, Stoneley M, Fraser GA, Willis AE (June 2001). "Derivation of a structural model for the c-myc IRES". Journal of Molecular Biology. 310 (1): 111–126. doi:10.1006/jmbi.2001.4745. PMID 11419940.

External links

Page for c-myc internal ribosome entry site (IRES) at Rfam

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[1] Le Quesne JP, Stoneley M, Fraser GA, Willis AE (June 2001). "Derivation of a structural model for the c-myc IRES". Journal of Molecular Biology. 310 (1): 111–126. doi:10.1006/jmbi.2001.4745. PMID 11419940.

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