4-hydroxy-tetrahydrodipicolinate reductase

In enzymology, a 4-hydroxy-tetrahydrodipicolinate reductase (EC 1.17.1.8) is an enzyme that catalyzes the chemical reaction

4-hydroxy-tetrahydrodipicolinate reductase
Dihydrodipicolinate reductase tetramer, Corynebacterium glutamicum
Identifiers
EC no.1.17.1.8
CAS no.9055-46-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+

The 3 substrates of this enzyme are (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, NAD+ or NADP+, and H2O, whereas its 3 products are (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate, NADH or NADPH, and H+.

This enzyme participates in lysine biosynthesis.

Nomenclature

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This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase. Other names in common use include:

  • dihydrodipicolinate reductase,
  • dihydrodipicolinic acid reductase, and
  • 2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase.

References

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Further reading

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  • Farkas W, Gilvarg C (Dec 1965). "The reduction step in diaminopimelic acid biosynthesis". The Journal of Biological Chemistry. 240 (12): 4717–22. doi:10.1016/S0021-9258(18)97014-6. PMID 4378965.
  • Tamir H (1971). "Dihydrodipicolinic acid reductase (Escherichia coli)". Metabolism of Amino Acids and Amines Part B. Methods Enzymol. Vol. 17B. pp. 134–139. doi:10.1016/0076-6879(71)17030-9. ISBN 978-0-12-181877-7.
  • Devenish SR, Blunt JW, Gerrard JA (Jun 2010). "NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase". Journal of Medicinal Chemistry. 53 (12): 4808–12. doi:10.1021/jm100349s. PMID 20503968.