Iridoviridae is a family of viruses with double-stranded DNA genomes.[1] Amphibians, fish, and invertebrates such as arthropods serve as natural hosts. There are currently 22 species in this family, divided among two subfamilies and seven genera.[1][2]
| Iridoviridae | |
|---|---|
| |
| TEM micrograph showing a cluster of Iridovirus virions | |
Virus classification 
| |
| (unranked): | Virus |
| Realm: | Varidnaviria |
| Kingdom: | Bamfordvirae |
| Phylum: | Nucleocytoviricota |
| Class: | Megaviricetes |
| Order: | Pimascovirales |
| Family: | Iridoviridae |
| Subfamilies and genera | |
|
See text | |
Nomenclature
editThe name is derived from Iris, the Greek goddess of the rainbow. This name was chosen because of the "rainbow-like" iridescence observed in heavily infected insects and pelleted samples of invertebrate iridoviruses. It may refer to any member of the Iridoviridae family or a particular genus within Iridoviridae.[citation needed]
Taxonomy
editThe following subfamilies and genera are recognized (-virinae denotes subfamily and -virus denotes genus):[citation needed]
Structure
editThe virions are icosahedral with triangulation number (T) = 189–217, 120–350 nm in diameter and made up of three domains: an outer proteinaceous capsid, an intermediate lipid membrane, and a central core containing DNA-protein complexes. Some of the viruses also have an outer envelope. The presence or absence of an envelope depends on whether they budded from the cell membrane (enveloped viruses) or were arranged in paracrystalline arrays within the host cell cytoplasm and then were released by cell lysis (unenveloped viruses).[citation needed]
The linear genome varies between 150 and 303 kilobases in length. It contains terminal and redundant sequences and is circularly permuted.[citation needed]
Members of this family differ in their degree of genome methylation. The genera Chloriridovirus and Iridovirus lack a highly methylated genome. Members of Lymphocystivirus, Megalocytivirus, and Ranavirus have genomes with about 25% of their cytosine residues methylated by a virally encoded DNA methyltransferase.[citation needed]
| Genus | Structure | Symmetry | Genomic arrangement | Genomic segmentation |
|---|---|---|---|---|
| Lymphocystivirus | Polyhedral | T=189–217 | Linear | Monopartite |
| Megalocytivirus | Polyhedral | T=189–217 | Linear | Monopartite |
| Ranavirus | Polyhedral | T=133 or 147 | Linear | Monopartite |
| Iridovirus | Polyhedral | T=147 | Linear | Monopartite |
| Chloriridovirus | Polyhedral | T=189–217 | Linear | Monopartite |
Gene expression
editSimilar to the herpes viruses, transcription occurs in three stages: immediate-early, delayed-early, and late. Positive induction and negative feedback mechanisms exist in each stage, mediated by products of the other stages.[citation needed]
Replication
editVirus particles enter the cell and uncoating occurs. The viral DNA is transported to the host cell nucleus, where it is transcribed by host RNA polymerase II modified by the virus. Meanwhile, host macromolecular synthesis ceases.
Parental DNA produces a genome which is then the template for replication in the cytoplasm. Large concatemers of viral DNA are formed by recombination in the cytoplasm. Packaging of the new genomes into virions occurs in the cytoplasm and the virus is released either by budding from the cell membrane or cell lysis.
| Genus | Host details | Tissue tropism | Entry details | Release details | Replication site | Assembly site | Transmission |
|---|---|---|---|---|---|---|---|
| Lymphocystivirus | Fish | None | Cell receptor endocytosis | Lysis; budding | Nucleus | Cytoplasm | Unknown |
| Megalocytivirus | Fish | None | Cell receptor endocytosis | Lysis; budding | Nucleus | Cytoplasm | Unknown |
| Ranavirus | Frogs; snakes | None | Cell receptor endocytosis | Lysis; budding | Nucleus | Cytoplasm | Contact |
| Iridovirus | Insects | None | Cell receptor endocytosis | Lysis; budding | Nucleus | Cytoplasm | Contact |
| Chloriridovirus | Diptera with aquatic larval stage, mainly mosquitoes | None | Cell receptor endocytosis | Budding | Nucleus | Cytoplasm | Unknown |
DNA repair
editMembers of the Iridoviridae appear to have the capability to repair DNA damages.[3]
Pathogenesis
editLittle is known about the pathogenesis of iridoviruses. The pathogenesis is, however, temperature dependent and iridoviruses are thus confined to poikilothermic hosts.[citation needed]
Host range
editMembers of the Iridoviridae family infect mainly invertebrates, but also some vertebrate species such as fish, amphibians and reptiles.[citation needed]
References
edit- ^ a b "Iridoviridae". ICTV Online (10th) Report.
- ^ "Viral Zone". ExPASy. Retrieved 15 June 2015.
- ^ Ke F, Zhang QY. ADRV 12L: A Ranaviral Putative Rad2 Family Protein Involved in DNA Recombination and Repair. Viruses. 2022 Apr 27;14(5):908. doi: 10.3390/v14050908. PMID 35632650; PMCID: PMC9146916
MicrobiologyBytes: Iridoviruses, archived from the original on February 24, 2007, retrieved 2007-03-06 Viral Bioinformatics Resource Center & Viral Bioinformatics – Canada, University of Victoria, archived from the original on August 17, 2007, retrieved 2007-03-06
External links
edit
