USS Defiance may refer to the following ships of the United States Navy:
- USS Defiance (ID-3327), a cargo vessel in service from 1918–1919
- USS Defiance (AMc-73), a coastal minesweeper that served during World War II
- USS Defiance (PG-95), a patrol gunboat that served from 1969 until 1973 when it was transferred to Turkey
See also
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This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.