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{{short description|Chemical compound}}
{{Drugbox
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<!--Identifiers-->
<!-- Identifiers -->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number_Ref = {{cascite|correct|CAS}}
| CAS_number = 36975-99-2
| CAS_number = 36975-99-2
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = PX48L7VRQ2
| ATC_prefix = none
| ATC_prefix = none
| PubChem = 37594
| PubChem = 37594
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<!--Chemical data-->
<!--Chemical data-->
| C=15 | H=12 | N=4 | O=3
| C=15 | H=12 | N=4 | O=3
| molecular_weight = 296.280 g/mol
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C15H12N4O3/c16-14-9-15(20)18(10-4-2-1-3-5-10)13-8-11(19(21)22)6-7-12(13)17-14/h1-8H,9H2,(H2,16,17)
| StdInChI = 1S/C15H12N4O3/c16-14-9-15(20)18(10-4-2-1-3-5-10)13-8-11(19(21)22)6-7-12(13)17-14/h1-8H,9H2,(H2,16,17)
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'''CP-1414S''' is an experimental drug first made by a team in Germany.<ref>US 3766169</ref> It is a [[benzodiazepine]] derivative. CP-1414S is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as [[clobazam]].
'''CP-1414S''' is an experimental drug first made by a team in Germany.<ref>US Patent 3766169 PROCESS FOR THE PREPARATION OF 3-AMINOMETHYLIDENE-1,5-BENZODIAZEPINE-2,4-(3H,5H)-DIONES</ref> It is a [[benzodiazepine]] derivative. CP-1414S is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as [[clobazam]].


CP-1414S has primarily [[anxiolytic]] and [[anticonvulsant]] effects.<ref name="pmid6119091">{{cite journal |vauthors=Carli M, Ballabio M, Caccia S, Garattini S, Samanin R |title=Studies on some pharmacological activities of 7-nitro-2-amino-5-phenyl-3H-1,5-benzodiazepine (CP 1414 S) in the rat. A comparison with diazepam |journal=Arzneimittel-Forschung |volume=31 |issue=10 |pages=1721–3 |year=1981 |pmid=6119091 |doi= |url=}}</ref> Its potency is roughly equal to that of [[clobazam]], but with more pronounced sedation.<ref name="pmid6129557">{{cite journal |vauthors=Mennini T, Garattini S |title=Benzodiazepine receptors': correlation with pharmacological responses in living animals |journal=Life Sciences |volume=31 |issue=19 |pages=2025–35 |date=November 1982 |pmid=6129557 |doi= 10.1016/0024-3205(82)90094-7|url=}}</ref>
CP-1414S has primarily [[anxiolytic]] and [[anticonvulsant]] effects.<ref name="pmid6119091">{{cite journal |vauthors=Carli M, Ballabio M, Caccia S, Garattini S, Samanin R |title=Studies on some pharmacological activities of 7-nitro-2-amino-5-phenyl-3H-1,5-benzodiazepine (CP 1414 S) in the rat. A comparison with diazepam |journal=Arzneimittel-Forschung |volume=31 |issue=10 |pages=1721–3 |year=1981 |pmid=6119091 }}</ref> Its potency is roughly equal to that of [[clobazam]], but with more pronounced sedation.<ref name="pmid6129557">{{cite journal |vauthors=Mennini T, Garattini S |title=Benzodiazepine receptors': correlation with pharmacological responses in living animals |journal=Life Sciences |volume=31 |issue=19 |pages=2025–35 |date=November 1982 |pmid=6129557 |doi= 10.1016/0024-3205(82)90094-7}}</ref>


==See also==
==See also==

Latest revision as of 20:13, 4 November 2022

CP-1414S
Clinical data
ATC code
  • none
Identifiers
  • 1-phenyl-4-amino-8-nitro-3H-1,5-benzodiazepin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H12N4O3
Molar mass296.286 g·mol−1
  • InChI=1S/C15H12N4O3/c16-14-9-15(20)18(10-4-2-1-3-5-10)13-8-11(19(21)22)6-7-12(13)17-14/h1-8H,9H2,(H2,16,17) checkY
  • Key:MBSVPZTUXNRICW-UHFFFAOYSA-N checkY
  (verify)

CP-1414S is an experimental drug first made by a team in Germany.[1] It is a benzodiazepine derivative. CP-1414S is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam.

CP-1414S has primarily anxiolytic and anticonvulsant effects.[2] Its potency is roughly equal to that of clobazam, but with more pronounced sedation.[3]

See also

[edit]

References

[edit]
  1. ^ US Patent 3766169 PROCESS FOR THE PREPARATION OF 3-AMINOMETHYLIDENE-1,5-BENZODIAZEPINE-2,4-(3H,5H)-DIONES
  2. ^ Carli M, Ballabio M, Caccia S, Garattini S, Samanin R (1981). "Studies on some pharmacological activities of 7-nitro-2-amino-5-phenyl-3H-1,5-benzodiazepine (CP 1414 S) in the rat. A comparison with diazepam". Arzneimittel-Forschung. 31 (10): 1721–3. PMID 6119091.
  3. ^ Mennini T, Garattini S (November 1982). "Benzodiazepine receptors': correlation with pharmacological responses in living animals". Life Sciences. 31 (19): 2025–35. doi:10.1016/0024-3205(82)90094-7. PMID 6129557.


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