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A uterotonic is an agent used to induce contraction or greater tonicity of the uterus. Uterotonics are used both to induce labor, and to reduce postpartum hemorrhage.

Some uterotonics act as analogues of oxytocin. An oxytocinergic, or oxytocic, means "having to do with oxytocin (OXT)". The Oxytocin Receptor (OXTR) is the binding and activation site of oxytocin.

Some agents may act as indirect oxytocinergics:

5-HT_1A Receptor (5-HT_1AR): A protein responsible for inducing the secretion of oxytocin.
Serotonergic: A drug which acts upon serotonin and 5-HT_1AR, resulting in oxytocin release (e.g., MDMA ("Ecstasy").

Other uterotonics include Methylergonovine and Prostaglandin F2.

A tocolytic acts to oppose uterine contractility. These agents may be oxytocinergic in mechanism. For example, Atosiban works in this way.

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v t e Anxiolytics (N05B)
5-HT_1ARTooltip 5-HT1A receptor agonists	Buspirone Gepirone Tandospirone
GABA_ARTooltip GABAA receptor PAMsTooltip positive allosteric modulators	Benzodiazepines: Adinazolam Alprazolam Bromazepam Camazepam Chlordiazepoxide Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam^# Ethyl loflazepate Etizolam Fludiazepam Halazepam Ketazolam Lorazepam^# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem^‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Carisoprodol Chlormezanone^‡ Ethanol (alcohol) Etifoxine
Hypnotics	Zopiclone
Gabapentinoids (α₂δ VDCC blockers)	Gabapentin Gabapentin enacarbil Phenibut Pregabalin
Antidepressants	SSRIsTooltip Selective serotonin reuptake inhibitors (e.g., escitalopram) SNRIsTooltip Serotonin-norepinephrine reuptake inhibitors (e.g., duloxetine) SARIsTooltip Serotonin antagonist and reuptake inhibitors (e.g., trazodone) TCAsTooltip Tricyclic antidepressants (e.g., clomipramine^#) TeCAsTooltip Tetracyclic antidepressants (e.g., mirtazapine) MAOIsTooltip Monoamine oxidase inhibitors (e.g., phenelzine); Others: Agomelatine Bupropion Tianeptine Vilazodone Vortioxetine
Antipsychotics	Quetiapine Flupentixol
Sympatholytics (Antiadrenergics)	Alpha-1 blockers (e.g., prazosin) Alpha-2 agonists (e.g., clonidine, dexmedetomidine, guanfacine) Beta blockers (e.g., propranolol)
Others	Benzoctamine Cycloserine Fabomotizole Hydroxyzine Lorpiprazole Mebicar Mepiprazole Nicotine Opipramol Oxaflozane^‡ Phenaglycodol Phenibut Picamilon Selank Tiagabine Tofisopam Validolum
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

Uterotonics/labor inducers/oxytocics (G02A)

Cervical ripening

Ergot alkaloids	Acetergamine Ergometrine^# (Syntometrine) Methylergometrine
Prostaglandins and analogues	E: Misoprostol/E1^# Gemeprost/E1 Dinoprostone/E2 Sulprostone/E2 F: Dinoprost/F2α Carboprost/F2α

Contraction induction

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Template:Neuropeptide agonists and antagonists

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Revision as of 23:34, 15 June 2012 edit 174.227.2.238 (talk) →See also: Goldenseal ← Previous edit		Revision as of 20:03, 6 July 2013 edit undo EndlessVince (talk \| contribs) Extended confirmed users 775 edits No edit summary Tag: Visual edit Next edit →
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	A '''uterotonic''' is an agent used to induce contraction or greater [[tonicity]] of the uterus. Uterotonics are used both to [[~~Childbirth~~\|induce labor]], and to reduce [[postpartum hemorrhage]].		A '''uterotonic''' is an agent used to induce contraction or greater [[tonicity]] of the uterus. Uterotonics are used both to [[Induction of labor\|induce labor]], and to reduce [[postpartum hemorrhage]].

	Some uterotonics act as analogues of [[oxytocin]]. An '''oxytocinergic''', or '''oxytocic''', means "having to do with [[oxytocin]] (OXT)". The [[Oxytocin receptor\|Oxytocin Receptor]] (OXTR) is the [[binding (molecular)\|binding]] and [[active site\|activation site]] of oxytocin.		Some uterotonics act as analogues of [[oxytocin]]. An '''oxytocinergic''', or '''oxytocic''', means "having to do with [[oxytocin]] (OXT)". The [[Oxytocin receptor\|Oxytocin Receptor]] (OXTR) is the [[binding (molecular)\|binding]] and [[active site\|activation site]] of oxytocin.

Revision as of 20:03, 6 July 2013

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References