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ENZYME

ENZYME entry: EC 2.1.1.245

Accepted Name
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase
Reaction catalysed
5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)
Comment(s)
  • Catalyzes the transfer of a methyl group from the cobamide cofactor of a corrinoid/Fe-S protein to the N5 group of tetrahydrosarcinapterin.
  • Forms, together with EC 1.2.7.4 and EC 2.3.1.169 the acetyl-CoA decarbonylase/synthase complex that catalyzes the demethylation of acetyl-CoA in a reaction that also forms CO2.
  • This reaction is a key step in methanogenesis from acetate.
Cross-references
BRENDA2.1.1.245
EC2PDB2.1.1.245
ExplorEnz2.1.1.245
KEGG Ligand Database for Enzyme Nomenclature2.1.1.245
IUBMB Enzyme Nomenclature2.1.1.245
MEDLINEFind literature relating to 2.1.1.245
MetaCyc2.1.1.245
Rhea expert-curated reactions2.1.1.245
UniProtKB/Swiss-Prot
Q8PZ09, ACDG1_METMAQ50539, ACDG1_METTEQ8PV87, ACDG2_METMA
Q9C4Z0, ACDG2_METTEO29871, ACDG_ARCFUQ8TH44, ACDG_METAC
Q57576, ACDG_METJAQ8TXF1, ACDG_METKAO27748, ACDG_METTH

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