Expasy logo

ENZYME

ENZYME entry: EC 2.3.1.241

Accepted Name
Kdo2-lipid IVA acyltransferase
Alternative Name(s)
(Kdo)2-lipid IVA lauroyltransferase
alpha-Kdo-(2->4)-alpha-(2->6)-lipid IVA lauroyltransferase
Kdo2-lipid IVA lauroyltransferase
Reaction catalysed
an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a fatty acyl-[ACP] = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]
Comment(s)
  • The enzyme is involved in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A.
  • It transfers an acyl group to the 3-O position of the 3R-hydroxyacyl already attached to the nitrogen of the non-reducing glucosamine molecule.
  • The enzyme from the bacterium Escherichia coli is specific for lauryl (C12) acyl groups, giving the enzyme its previous accepted name.
  • However, enzymes from different species accept highly variable substrates.
Cross-references
BRENDA2.3.1.241
EC2PDB2.3.1.241
ExplorEnz2.3.1.241
KEGG Ligand Database for Enzyme Nomenclature2.3.1.241
IUBMB Enzyme Nomenclature2.3.1.241
MEDLINEFind literature relating to 2.3.1.241
MetaCyc2.3.1.241
Rhea expert-curated reactions2.3.1.241
UniProtKB/Swiss-Prot
P0ACV1, LPXL_ECO57P0ACV0, LPXL_ECOLIP45239, LPXL_HAEIN

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-