ENZYME entry: EC 2.3.1.252

Accepted Name

mycolipanoate synthase

Alternative Name(s)

mycolipanoic acid synthase

Reaction catalysed

holo-[mycolipanoate synthase] + a long-chain fatty acyl-CoA + 3 (S)-methylmalonyl-CoA + 6 NADPH + 9 H(+) = long-chain mycolipanoyl-[mycolipanoate synthase] + 3 CO2 + 6 NADP(+) + 4 CoA + 3 H2O

Comment(s)

This mycobacterial enzyme accepts long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three methylmalonyl (but not malonyl) residues, forming trimethyl-branched fatty-acids such as (2S,4S,6S)-2,4,6-trimethyl-tetracosanoate (C27- mycolipanoate).
Since the enzyme lacks a thioesterase domain, the product remains bound to the enzyme and requires additional enzyme(s) for removal.

Cross-references

BRENDA

2.3.1.252

EC2PDB

2.3.1.252

ExplorEnz

2.3.1.252

KEGG Ligand Database for Enzyme Nomenclature

2.3.1.252

IUBMB Enzyme Nomenclature

2.3.1.252

MEDLINE

Find literature relating to 2.3.1.252

MetaCyc

2.3.1.252

Rhea expert-curated reactions

2.3.1.252

UniProtKB/Swiss-Prot

A0A089QRB9, MSL3_MYCTU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-