Expasy logo

ENZYME

ENZYME entry: EC 2.5.1.87

Accepted Name
ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]
Alternative Name(s)
dehydrodolichyl diphosphate synthase 1
Rer2p Z-prenyltransferase
Reaction catalysed
n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate
Comment(s)
  • The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated alpha-isoprene unit, which serves as a glycosyl carrier in protein glycosylation.
  • The yeast Saccharomyces cerevisiae has two different enzymes that catalyze this reaction.
  • Rer2p synthesizes a well-defined family of polyprenols of 13-18 isoprene residues with dominating C80 (16 isoprene residues) extending to C120, while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits.
  • Largest Srt1p products reach C290.
  • The enzyme from Arabidopsis thaliana catalyzes the formation of polyprenyl diphosphates with predominant carbon number C120.
Cross-references
BRENDA2.5.1.87
EC2PDB2.5.1.87
ExplorEnz2.5.1.87
KEGG Ligand Database for Enzyme Nomenclature2.5.1.87
IUBMB Enzyme Nomenclature2.5.1.87
MEDLINEFind literature relating to 2.5.1.87
MetaCyc2.5.1.87
Rhea expert-curated reactions2.5.1.87
UniProtKB/Swiss-Prot
K7WCI9, CPT3_SOLLCK7X479, CPT5_SOLLCO80458, DDPS1_ARATH
Q86SQ9, DHDDS_HUMANQ99KU1, DHDDS_MOUSEP60478, DPDS_MYCBO
P38119, DPDS_MYCLEA0R0S4, DPDS_MYCS2P9WFF6, DPDS_MYCTO
P9WFF7, DPDS_MYCTUQ6DHR8, NGBR_DANREQ96E22, NGBR_HUMAN
Q99LJ8, NGBR_MOUSEP35196, RER2_YEASTQ03175, SRT1_YEAST
Q9Y7K8, UPPS_SCHPOQ12063, UPPS_YEASTO14171, YE54_SCHPO

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-