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ENZYME

ENZYME entry: EC 2.8.2.35

Accepted Name
dermatan 4-sulfotransferase
Alternative Name(s)
CHST14 protein
dermatan N-acetylgalactosamine 4-O-sulfotransferase
dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase
Reaction catalysed
dermatan + n 3'-phosphoadenylyl sulfate = dermatan 4'-sulfate + n adenosine 3',5'-bisphosphate + n H(+)
Comment(s)
  • The sulfation takes place at the 4-position of N-acetylgalactosamine residues of dermatan.
  • D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha(1,3)GalNAcbeta(1,4) that is flanked by GlcUAbeta(1,3)GalNAcbeta(1,4) as compared with IdoUAalpha(1,3)GalNAcbeta(1,4) flanked by IdoUAalpha(1,3)GalNAcbeta(1,4).
Cross-references
BRENDA2.8.2.35
EC2PDB2.8.2.35
ExplorEnz2.8.2.35
KEGG Ligand Database for Enzyme Nomenclature2.8.2.35
IUBMB Enzyme Nomenclature2.8.2.35
MEDLINEFind literature relating to 2.8.2.35
MetaCyc2.8.2.35
Rhea expert-curated reactions2.8.2.35
UniProtKB/Swiss-Prot
Q8NCH0, CHSTE_HUMANQ80V53, CHSTE_MOUSE

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