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ENZYME

ENZYME entry: EC 4.2.3.12

Accepted Name
6-pyruvoyltetrahydropterin synthase
Alternative Name(s)
6-pyruvoyl tetrahydrobiopterin synthase
PTPS
Reaction catalysed
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate + H(+)
Comment(s)
  • Catalyzes triphosphate elimination and an intramolecular redox reaction.
  • The product is 6-pyruvoyltetrahydrobiopterin.
  • Involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 and EC 3.5.4.16.
  • Formerly EC 4.6.1.10.
Cross-references
BRENDA4.2.3.12
EC2PDB4.2.3.12
ExplorEnz4.2.3.12
KEGG Ligand Database for Enzyme Nomenclature4.2.3.12
IUBMB Enzyme Nomenclature4.2.3.12
MEDLINEFind literature relating to 4.2.3.12
MetaCyc4.2.3.12
Rhea expert-curated reactions4.2.3.12
UniProtKB/Swiss-Prot
O02058, PTPS_CAEELQ1ZXI0, PTPS_DICDIP48611, PTPS_DROME
Q03393, PTPS_HUMANQ9R1Z7, PTPS_MOUSEQ90W95, PTPS_POERE
Q5REZ5, PTPS_PONABP27213, PTPS_RATP80081, PTPS_SALSA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-