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ENZYME

ENZYME entry: EC 6.3.2.12

Accepted Name
dihydrofolate synthase
Alternative Name(s)
7,8-dihydrofolate synthetase
DHFS
dihydrofolate synthetase
H2-folate synthetase
Reaction catalysed
7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)
Comment(s)
  • In some bacteria, a single protein catalyzes both this activity and that of EC 6.3.2.17, the combined activity of which leads to the formation of the cofactor polyglutamated tetrahydropteroate (H4PteGlun), i.e. various tetrahydrofolates.
  • In contrast, the activities are located on separate proteins in most eukaryotes studied to date.
  • This enzyme is reponsible for attaching the first glutamate residue to dihydropteroate to form dihydrofolate and is present only in those organisms that have the ability to synthesize tetrahydrofolate de novo, e.g. plants, most bacteria, fungi and protozoa.
Cross-references
BRENDA6.3.2.12
EC2PDB6.3.2.12
ExplorEnz6.3.2.12
KEGG Ligand Database for Enzyme Nomenclature6.3.2.12
IUBMB Enzyme Nomenclature6.3.2.12
MEDLINEFind literature relating to 6.3.2.12
MetaCyc6.3.2.12
Rhea expert-curated reactions6.3.2.12
UniProtKB/Swiss-Prot
F4JYE9, DHFS_ARATHQ05865, FOLC_BACSUP57265, FOLC_BUCAI
Q8K9X3, FOLC_BUCAPQ89AT2, FOLC_BUCBPP08192, FOLC_ECOLI
P43775, FOLC_HAEINI6Y0R5, FOLC_MYCTUQ9UTD0, FOLD_SCHPO
Q12676, FOLD_YEAST

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