The diagnostic role of retrograde pyelography in children with secondary hypertension has never b... more The diagnostic role of retrograde pyelography in children with secondary hypertension has never been discussed in the literature. We report a child with severe hypertension, who apparently has a normal renin level and a solitary kidney by renal sonography and renal scan. Retrograde pyelography was able to identify the scarred renal mass. To our knowledge this is the first report to discuss the role of retrograde pyelography in a child with a solitary kidney and severe hypertension.
A 17-year-old white male with a diagnosis of Guillain-BarrØ syndrome (GBS) developed severe pro-t... more A 17-year-old white male with a diagnosis of Guillain-BarrØ syndrome (GBS) developed severe pro-teinuria and edema 5 days later. Renal biopsy confirmed minimal change nephrotic syndrome (MCNS). To our knowledge this is the first report of such an association between ex novo MCNS and GBS in a pediatric patient. The NS responded to steroid therapy. The pertinent literature is reviewed.
Chronic arthritis in children is one of the most common rheumatic diseases of childhood. It is al... more Chronic arthritis in children is one of the most common rheumatic diseases of childhood. It is also one of the more frequent chronic illnesses of children and an important cause of short and long term disability. Although it has been customary to refer to this disorder as a single disease, it almost certainly comprises a number of similar entities , characterized by arthritis of the appendicular joints, each of which has distinct modes of presentation and may have the same or different causes. In order to more accurately assess the childhood arthritis and to better understand its etiology, it is necessary to scrupulously define the diseases which cause arthritis in children. In general, criteria for the classification of the idiopathic arthritides of childhood are intended to subdivide childhood onset arthritides in a manner that allows better understanding of their pathogenesis and treatment. 1,2 The purpose of these strict and sometimes confusing subtypes is to stratify patients entered into studies into homogeneous groups.
Overlap syndromes, such as scleromyositis, antisynthetase syndrome and mixed connective tissue di... more Overlap syndromes, such as scleromyositis, antisynthetase syndrome and mixed connective tissue disease , consist of a blend of clinical features involved in two separate autoimmune disorders. Scleromyositis, the most common overlap syndrome, is usually observed in adults, and has rarely been documented in childhood. Here, the case of a 10-year-old African American female with scleromyositis is reported. This disease has features of both dermatomyositis and systemic scleroderma. Her disease process began with signs and symptoms of dermatomyositis and slowly changed clinically to features of systemic sclero-derma. This patient had a positive ANA with a nucleolar pattern and a negative anti-PM/Scl antibody, an antibody which has been used as a prognostic and diagnostic marker of scleromyositis.
Accurate diagnosis of acute pyelonephritis (APN) using clinical and laboratory parameters is ofte... more Accurate diagnosis of acute pyelonephritis (APN) using clinical and laboratory parameters is often difficult in children. The aims of this retrospective study were twofold. Firstly, to correlate the clinical and laboratory manifestations of APN with the results of the dimer-captosuccinic acid (DMSA) renal scan in different age groups. Secondly, to compare the DMSA renal scan, re-nal ultrasonography (RUS), and voiding cystourethrogra-phy (VCUG) in patients with clinical APN. The DMSA renal scan was utilized as the gold standard for renal involvement. We determined the sensitivity of these tests in febrile urinary tract infections (UTI) in three age groups: group I less than 2 years; group II 2–8 years; group III older than 8 years. During the period January 1992 through December 1998, 222 children presented with a febrile UTI. All patients had a DMSA renal scan, 208 had contrast VCUG, and 163 had RUS. The clinical and laboratory manifestation of pyelonephritis correlated better with a positive DMSA renal scan in the older children than in the younger children; 85% of the DMSA re-nal scans were positive in group III; 69% in group II; 48% in group I (P<0.001). Vesicoureteral reflux detected by contrast VCUG was more prevalent in the younger age groups. Although high grades of reflux (grade IV–V) correlated better with a positive DMSA renal scan, it did not reach a level of statistical significance (P>0.05). RUS did not correlate with a positive DMSA renal scan in any age group.
Proceedings of the National Academy of Sciences of the United States of America, 2005
Apc Min mice have provided an example of a locus (Modifier of Min1; Mom1) modifying adenoma numbe... more Apc Min mice have provided an example of a locus (Modifier of Min1; Mom1) modifying adenoma numbers in the intestines of inbred strains. Linkage analysis located Mom1 on chromosome 4, and further investigation identified secretory phospholipase A2 (Pla2g2a) as a candidate gene. Because of unknown variation introduced by a single founding male mouse, our Min stock, although Pla2g2a Mom1-s , was not on a pure C57BL͞6J background and exhibited several polymorphic loci, including a region on chromosome 18 distal to Apc. Through selective breeding for homozygosity for distal chromosome 18 markers, six recombinant lines that presented with limited intraline variation in adenoma numbers were established. One line (V) showed a particularly severe phenotype (mean adenoma number ؎ SEM, 370 ؎ 21) compared with the other lines that recorded significantly lower means (3-to 5-fold; P < 10 ؊3 , t test). Intercrosses between lines I and V showed suppression of the severe phenotype in the N1 generation. In N2 (and subsequent) backcrosses, tumor multiplicity depended on the origins of the WT and Min Apc alleles. Mice carrying both alleles from line V had a severe phenotype; others had mild disease very similar to line I (likelihood ratio statistic > 49.0; likelihood of odds > 10; P < 10 ؊5 ). Frequency of allele loss at Apc was increased significantly in adenomas of mice with more severe disease. We propose that a modifier gene close to Apc or structural variation on chromosome 18 modifies polyp numbers in our mice, possibly by altering the frequency of WT Apc allele loss.
Proceedings of the National Academy of Sciences of the United States of America, Jan 16, 1999
The type II transforming growth factor (TGF)-beta receptor gene (TGFBR2) is often mutated in nucl... more The type II transforming growth factor (TGF)-beta receptor gene (TGFBR2) is often mutated in nucleotide repeat sequences in colorectal cancers that are replication error positive (RER+). These mutations are thought to be selected for escape from growth inhibition by TGF-beta rather than representing bystander events because of an increased mutation rate. We investigated the role of TGFBR2 mutations in 12 colorectal cancer cell lines. Six of these were RER+, and these were shown to have homozygous TGFBR2 mutations. All cell lines then were tested for changes in proliferation in response to TGF-beta stimulation. Despite homozygous mutation of the type II TGF-beta receptor, two RER+ cell lines, Lovo and SW48, showed statistically significant growth inhibition when stimulated by TGF-beta1 in serum-free conditions. This shows that the type II TGF-beta receptor can be bypassed in certain cases to maintain growth inhibition. We next investigated whether there was any alternative mode throu...
Proceedings of the National Academy of Sciences of the United States of America, Jan 16, 1999
Mutations in the adenomatous polyposis coli or beta-catenin gene lead to cytosolic accumulation o... more Mutations in the adenomatous polyposis coli or beta-catenin gene lead to cytosolic accumulation of beta-catenin and, subsequently, to increased transcriptional activity of the beta-catenin-T cell-factor/lymphoid-enhancer-factor complex. This process seems to play an essential role in the development of most colorectal carcinomas. To identify genes activated by beta-catenin overexpression, we used colorectal cell lines for transfection with the beta-catenin gene and searched for genes differentially expressed in the transfectants. There are four genes affected by beta-catenin overexpression; three overexpressed genes code for two components of the AP-1 transcription complex, c-jun and fra-1, and for the urokinase-type plasminogen activator receptor (uPAR), whose transcription is activated by AP-1. The direct interaction of the beta-catenin-T cell-factor/lymphoid-enhancer-factor complex with the promoter region of c-jun and fra-1 was shown in a gel shift assay. The concomitant increas...
Picture from: http://hubpages.com/hub/DNA-Testingfor-Disease-Prevention _________________________... more Picture from: http://hubpages.com/hub/DNA-Testingfor-Disease-Prevention _____________________________________________________________ Aims of the project 1. To make significant international contributions in elucidating the genetic background of attenuated colon polyposis (AFAP), based on regional and national patient cohorts.
^^^^ B . THE HANDBOOK OF AD HOC WIRELESS NETWORKS ' i . . . ; j^ H ' . Edited... more ^^^^ B . THE HANDBOOK OF AD HOC WIRELESS NETWORKS ' i . . . ; j^ H ' . Edited by Mohammad llyas .' PR1-SS ... THE HANDBOOK OF AD HOC WIREL NETWORKS This One 7YKY-BLD-WWKH ... The Electrical Engineering Handbook Series Series Editor Richard ...
Mediterranean Journal of Nutrition and Metabolism, 2011
Main objective of this research work was to develop yoghurt like fermented dairy product by repla... more Main objective of this research work was to develop yoghurt like fermented dairy product by replacing milk fat with enzymatically transesterified palm olein. Milk fat was replaced with enzymatically transesterified palm olein at different levels, i.e., T 1 (1.5% enzymatically transesterified palm olein and 2% milk fat), T 2 (2.5% enzymatically transesterified palm olein and 1% milk fat), T 3 (3.5% enzymatically transesterified palm olein and 0% milk fat). All these treatments were compared with a control T 0 which did not contain any vegetable fat replacement (3.5% milk fat). Yoghurt like fermented dairy product was prepared from buffalo milk and stored for 21 days at 4°C. The addition of enzymatically transesterified palm olein on physico-chemical analysis and sensory characteristics were determined at the interval of 7 days. Incorporation of palm olein up to T 1 level did not have any adverse effect on compositional attributes, pH and acidity of yoghurt like fermented dairy product, flavor, texture and overall acceptability scores.
APC is often cited as a prime example of a tumor suppressor gene. Truncating germline and somatic... more APC is often cited as a prime example of a tumor suppressor gene. Truncating germline and somatic mutations (or, infrequently, allelic loss) occur in tumors in FAP (familial adenomatous polyposis). Most sporadic colorectal cancers also have two APC mutations. Clues from attenuated polyposis, missense germline variants with mild disease and the somatic mutation cluster region (codons 1,250-1,450) indicate, however, that APC mutations might not result in simple loss of protein function. We have found that FAP patients with germline APC mutations within a small region (codons 1,194-1,392 at most) mainly show allelic loss in their colorectal adenomas, in contrast to other FAP patients, whose &#39;second hits&#39; tend to occur by truncating mutations in the mutation cluster region. Our results indicate that different APC mutations provide cells with different selective advantages, with mutations close to codon 1,300 providing the greatest advantage. Allelic loss is selected strongly in cells with one mutation near codon 1,300. A different germline-somatic APC mutation association exists in FAP desmoids. APC is not, therefore, a classical tumor suppressor. Our findings also indicate a new mechanism for disease severity: if a broader spectrum of mutations is selected in tumors, the somatic mutation rate is effectively higher and more tumors grow.
ATM networks integrate different communication services such as data, voice and video, which have... more ATM networks integrate different communication services such as data, voice and video, which have different traffic characteristics. To evaluate the performance of ATM networks, accurate traffic models that can capture the statistical characteristics of actual traffic are required. The traffic models are employed either as part of an analytical model, or to drive a discrete event simulation. This paper reviews
IEEE International Conference on Communications, World Prosperity Through Communications, 1989
A microprocessor with features designed specifically for digital signal processing and communicat... more A microprocessor with features designed specifically for digital signal processing and communications protocol processing, for applications in data transmission relative to multiple media access, is described. In comparison with current microprocessors, this processor has efficient and cost-effective computation power to meet the needs of future devices for integration of high-throughput multimedia networks. Current state of the art in media integration
The diagnostic role of retrograde pyelography in children with secondary hypertension has never b... more The diagnostic role of retrograde pyelography in children with secondary hypertension has never been discussed in the literature. We report a child with severe hypertension, who apparently has a normal renin level and a solitary kidney by renal sonography and renal scan. Retrograde pyelography was able to identify the scarred renal mass. To our knowledge this is the first report to discuss the role of retrograde pyelography in a child with a solitary kidney and severe hypertension.
A 17-year-old white male with a diagnosis of Guillain-BarrØ syndrome (GBS) developed severe pro-t... more A 17-year-old white male with a diagnosis of Guillain-BarrØ syndrome (GBS) developed severe pro-teinuria and edema 5 days later. Renal biopsy confirmed minimal change nephrotic syndrome (MCNS). To our knowledge this is the first report of such an association between ex novo MCNS and GBS in a pediatric patient. The NS responded to steroid therapy. The pertinent literature is reviewed.
Chronic arthritis in children is one of the most common rheumatic diseases of childhood. It is al... more Chronic arthritis in children is one of the most common rheumatic diseases of childhood. It is also one of the more frequent chronic illnesses of children and an important cause of short and long term disability. Although it has been customary to refer to this disorder as a single disease, it almost certainly comprises a number of similar entities , characterized by arthritis of the appendicular joints, each of which has distinct modes of presentation and may have the same or different causes. In order to more accurately assess the childhood arthritis and to better understand its etiology, it is necessary to scrupulously define the diseases which cause arthritis in children. In general, criteria for the classification of the idiopathic arthritides of childhood are intended to subdivide childhood onset arthritides in a manner that allows better understanding of their pathogenesis and treatment. 1,2 The purpose of these strict and sometimes confusing subtypes is to stratify patients entered into studies into homogeneous groups.
Overlap syndromes, such as scleromyositis, antisynthetase syndrome and mixed connective tissue di... more Overlap syndromes, such as scleromyositis, antisynthetase syndrome and mixed connective tissue disease , consist of a blend of clinical features involved in two separate autoimmune disorders. Scleromyositis, the most common overlap syndrome, is usually observed in adults, and has rarely been documented in childhood. Here, the case of a 10-year-old African American female with scleromyositis is reported. This disease has features of both dermatomyositis and systemic scleroderma. Her disease process began with signs and symptoms of dermatomyositis and slowly changed clinically to features of systemic sclero-derma. This patient had a positive ANA with a nucleolar pattern and a negative anti-PM/Scl antibody, an antibody which has been used as a prognostic and diagnostic marker of scleromyositis.
Accurate diagnosis of acute pyelonephritis (APN) using clinical and laboratory parameters is ofte... more Accurate diagnosis of acute pyelonephritis (APN) using clinical and laboratory parameters is often difficult in children. The aims of this retrospective study were twofold. Firstly, to correlate the clinical and laboratory manifestations of APN with the results of the dimer-captosuccinic acid (DMSA) renal scan in different age groups. Secondly, to compare the DMSA renal scan, re-nal ultrasonography (RUS), and voiding cystourethrogra-phy (VCUG) in patients with clinical APN. The DMSA renal scan was utilized as the gold standard for renal involvement. We determined the sensitivity of these tests in febrile urinary tract infections (UTI) in three age groups: group I less than 2 years; group II 2–8 years; group III older than 8 years. During the period January 1992 through December 1998, 222 children presented with a febrile UTI. All patients had a DMSA renal scan, 208 had contrast VCUG, and 163 had RUS. The clinical and laboratory manifestation of pyelonephritis correlated better with a positive DMSA renal scan in the older children than in the younger children; 85% of the DMSA re-nal scans were positive in group III; 69% in group II; 48% in group I (P<0.001). Vesicoureteral reflux detected by contrast VCUG was more prevalent in the younger age groups. Although high grades of reflux (grade IV–V) correlated better with a positive DMSA renal scan, it did not reach a level of statistical significance (P>0.05). RUS did not correlate with a positive DMSA renal scan in any age group.
Proceedings of the National Academy of Sciences of the United States of America, 2005
Apc Min mice have provided an example of a locus (Modifier of Min1; Mom1) modifying adenoma numbe... more Apc Min mice have provided an example of a locus (Modifier of Min1; Mom1) modifying adenoma numbers in the intestines of inbred strains. Linkage analysis located Mom1 on chromosome 4, and further investigation identified secretory phospholipase A2 (Pla2g2a) as a candidate gene. Because of unknown variation introduced by a single founding male mouse, our Min stock, although Pla2g2a Mom1-s , was not on a pure C57BL͞6J background and exhibited several polymorphic loci, including a region on chromosome 18 distal to Apc. Through selective breeding for homozygosity for distal chromosome 18 markers, six recombinant lines that presented with limited intraline variation in adenoma numbers were established. One line (V) showed a particularly severe phenotype (mean adenoma number ؎ SEM, 370 ؎ 21) compared with the other lines that recorded significantly lower means (3-to 5-fold; P < 10 ؊3 , t test). Intercrosses between lines I and V showed suppression of the severe phenotype in the N1 generation. In N2 (and subsequent) backcrosses, tumor multiplicity depended on the origins of the WT and Min Apc alleles. Mice carrying both alleles from line V had a severe phenotype; others had mild disease very similar to line I (likelihood ratio statistic > 49.0; likelihood of odds > 10; P < 10 ؊5 ). Frequency of allele loss at Apc was increased significantly in adenomas of mice with more severe disease. We propose that a modifier gene close to Apc or structural variation on chromosome 18 modifies polyp numbers in our mice, possibly by altering the frequency of WT Apc allele loss.
Proceedings of the National Academy of Sciences of the United States of America, Jan 16, 1999
The type II transforming growth factor (TGF)-beta receptor gene (TGFBR2) is often mutated in nucl... more The type II transforming growth factor (TGF)-beta receptor gene (TGFBR2) is often mutated in nucleotide repeat sequences in colorectal cancers that are replication error positive (RER+). These mutations are thought to be selected for escape from growth inhibition by TGF-beta rather than representing bystander events because of an increased mutation rate. We investigated the role of TGFBR2 mutations in 12 colorectal cancer cell lines. Six of these were RER+, and these were shown to have homozygous TGFBR2 mutations. All cell lines then were tested for changes in proliferation in response to TGF-beta stimulation. Despite homozygous mutation of the type II TGF-beta receptor, two RER+ cell lines, Lovo and SW48, showed statistically significant growth inhibition when stimulated by TGF-beta1 in serum-free conditions. This shows that the type II TGF-beta receptor can be bypassed in certain cases to maintain growth inhibition. We next investigated whether there was any alternative mode throu...
Proceedings of the National Academy of Sciences of the United States of America, Jan 16, 1999
Mutations in the adenomatous polyposis coli or beta-catenin gene lead to cytosolic accumulation o... more Mutations in the adenomatous polyposis coli or beta-catenin gene lead to cytosolic accumulation of beta-catenin and, subsequently, to increased transcriptional activity of the beta-catenin-T cell-factor/lymphoid-enhancer-factor complex. This process seems to play an essential role in the development of most colorectal carcinomas. To identify genes activated by beta-catenin overexpression, we used colorectal cell lines for transfection with the beta-catenin gene and searched for genes differentially expressed in the transfectants. There are four genes affected by beta-catenin overexpression; three overexpressed genes code for two components of the AP-1 transcription complex, c-jun and fra-1, and for the urokinase-type plasminogen activator receptor (uPAR), whose transcription is activated by AP-1. The direct interaction of the beta-catenin-T cell-factor/lymphoid-enhancer-factor complex with the promoter region of c-jun and fra-1 was shown in a gel shift assay. The concomitant increas...
Picture from: http://hubpages.com/hub/DNA-Testingfor-Disease-Prevention _________________________... more Picture from: http://hubpages.com/hub/DNA-Testingfor-Disease-Prevention _____________________________________________________________ Aims of the project 1. To make significant international contributions in elucidating the genetic background of attenuated colon polyposis (AFAP), based on regional and national patient cohorts.
^^^^ B . THE HANDBOOK OF AD HOC WIRELESS NETWORKS ' i . . . ; j^ H ' . Edited... more ^^^^ B . THE HANDBOOK OF AD HOC WIRELESS NETWORKS ' i . . . ; j^ H ' . Edited by Mohammad llyas .' PR1-SS ... THE HANDBOOK OF AD HOC WIREL NETWORKS This One 7YKY-BLD-WWKH ... The Electrical Engineering Handbook Series Series Editor Richard ...
Mediterranean Journal of Nutrition and Metabolism, 2011
Main objective of this research work was to develop yoghurt like fermented dairy product by repla... more Main objective of this research work was to develop yoghurt like fermented dairy product by replacing milk fat with enzymatically transesterified palm olein. Milk fat was replaced with enzymatically transesterified palm olein at different levels, i.e., T 1 (1.5% enzymatically transesterified palm olein and 2% milk fat), T 2 (2.5% enzymatically transesterified palm olein and 1% milk fat), T 3 (3.5% enzymatically transesterified palm olein and 0% milk fat). All these treatments were compared with a control T 0 which did not contain any vegetable fat replacement (3.5% milk fat). Yoghurt like fermented dairy product was prepared from buffalo milk and stored for 21 days at 4°C. The addition of enzymatically transesterified palm olein on physico-chemical analysis and sensory characteristics were determined at the interval of 7 days. Incorporation of palm olein up to T 1 level did not have any adverse effect on compositional attributes, pH and acidity of yoghurt like fermented dairy product, flavor, texture and overall acceptability scores.
APC is often cited as a prime example of a tumor suppressor gene. Truncating germline and somatic... more APC is often cited as a prime example of a tumor suppressor gene. Truncating germline and somatic mutations (or, infrequently, allelic loss) occur in tumors in FAP (familial adenomatous polyposis). Most sporadic colorectal cancers also have two APC mutations. Clues from attenuated polyposis, missense germline variants with mild disease and the somatic mutation cluster region (codons 1,250-1,450) indicate, however, that APC mutations might not result in simple loss of protein function. We have found that FAP patients with germline APC mutations within a small region (codons 1,194-1,392 at most) mainly show allelic loss in their colorectal adenomas, in contrast to other FAP patients, whose &#39;second hits&#39; tend to occur by truncating mutations in the mutation cluster region. Our results indicate that different APC mutations provide cells with different selective advantages, with mutations close to codon 1,300 providing the greatest advantage. Allelic loss is selected strongly in cells with one mutation near codon 1,300. A different germline-somatic APC mutation association exists in FAP desmoids. APC is not, therefore, a classical tumor suppressor. Our findings also indicate a new mechanism for disease severity: if a broader spectrum of mutations is selected in tumors, the somatic mutation rate is effectively higher and more tumors grow.
ATM networks integrate different communication services such as data, voice and video, which have... more ATM networks integrate different communication services such as data, voice and video, which have different traffic characteristics. To evaluate the performance of ATM networks, accurate traffic models that can capture the statistical characteristics of actual traffic are required. The traffic models are employed either as part of an analytical model, or to drive a discrete event simulation. This paper reviews
IEEE International Conference on Communications, World Prosperity Through Communications, 1989
A microprocessor with features designed specifically for digital signal processing and communicat... more A microprocessor with features designed specifically for digital signal processing and communications protocol processing, for applications in data transmission relative to multiple media access, is described. In comparison with current microprocessors, this processor has efficient and cost-effective computation power to meet the needs of future devices for integration of high-throughput multimedia networks. Current state of the art in media integration
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Papers by Mohammad Ilyas