Orlando Silva

Fundação Santo André, Aluno, Department Member

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Diederik Jacques

Broder Merkel

Technische Universität Bergakademie Freiberg

Mads Troldborg

The James Hutton Institute

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Wonyong Jang

Juan C Meza

University of California, Merced

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Sahand Nekoeian

Petroleum University of Technology,Iran

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Philip H Stauffer

Los Alamos National Laboratory

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Papers by Orlando Silva

Non-passive transport of volatile organic compounds in the unsaturated zone

Advances in Water Resources, 2007

1 2 A detailed model was formulated to describe the non-passive transport of water-soluble 3 chem... more 1 2 A detailed model was formulated to describe the non-passive transport of water-soluble 3 chemicals in the unsaturated zone and used to illustrate one-dimensional infiltration and 4 redistribution of alcohol-water mixtures. The model includes the dependence of density, 5 viscosity, surface tension, molecular diffusion coefficient in the liquid phase, and gas-liquid 6 partition coefficient on the aqueous mixture composition. It also takes into account the 7 decrease in the gas-liquid partition coefficient at high capillary pressures, in accordance with 8 Kelvin's equation for multi-component mixtures. Simulation of butanol-water mixtures 9 infiltration in sand was in agreement with the experimental data and simulations reported in 10 the literature. Simulation of methanol infiltration and redistribution in two different soils 11 showed that methanol concentration significantly affects volumetric liquid content and 12 concentration profiles, as well as the normalized volatilization and evaporation fluxes. 13 Dispersion in the liquid-phase was the predominant mechanism in the transport of methanol 14 when dispersivity at saturation was set to 7.8 cm. Liquid flow was mainly due to capillary 15 pressure gradients induced by changes in volumetric liquid content. However, for dispersivity 16 at saturation set to 0.2 cm, changes in surface tension due to variation in composition induced 17 important liquid flow and convection in the liquid-phase was the most active transport 18 mechanism. When the Kelvin effect was ignored within the soil, the gas-phase diffusion was 19 significantly lower, leading to lower evaporation flux of water and higher volumetric liquid 20 contents near the soil surface. 21 22 65 hydraulic head gradients, which increases the liquid fluxes and the solute transport. Smith and 66 Gillham [44] complemented their previous work with laboratory experiments conducted in 67 saturated-unsaturated column sand. In this second work, they also incorporated the effect of 68 concentration-dependent viscosity into their earlier model [43] to scale the unsaturated 69 hydraulic conductivity. From their experimental data and numerical simulations, they 70 distinguished two flow effects associated with concentration-dependent surface tension in the 71 vadose zone: (i) the transient unsaturated flow caused by changes in pressure head, and (ii) a 72 157 158

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A soil-water retention function that includes the hyper-dry region through the BET adsorption isotherm

Water Resources Research, 2007

Most existing full-range soil-water retention functions extend standard capillary pressure curves... more

Weekly Docetaxel/Carboplatin as Primary Systemic Therapy for HER2Negative Locally Advanced Breast Cancer

Clinical Breast Cancer, 2005

To evaluate the effectiveness and safety of weekly docetaxel/carboplatin as primary systemic ther... more To evaluate the effectiveness and safety of weekly docetaxel/carboplatin as primary systemic therapy (PST) for locally advanced breast cancer, we conducted a phase II study. Forty-four patients with HER2-negative locally advanced or inflammatory breast cancer (IBC) received docetaxel 35 mg/m 2 and carboplatin to an area under the curve of 2 mg/mL/min for 3 of 4 weeks over 16 weeks. After completion of PST, patients had breast surgery and then received 4 cycles of adjuvant cyclophosphamide/doxorubicin, standard radiation therapy, and, for hormone receptor-positive tumors, tamoxifen. The mean tumor size was 9.3 cm (range, 5-24 cm). Thirty-seven patients (85%) had palpable lymph nodes; 13 patients (30%) had matted or fixed nodes (N2). Eight patients had IBC. There were 11 clinical complete responses (25%) and 29 clinical partial responses (66%), resulting in 40 objective responses (91% [95% CI, 78%-96%]). Invasive disease disappeared (pathologic complete response) from the breast and axilla in 6 patients (14% [95% CI, 5%-27%]) and from the axilla in 17 patients (39% [95% CI, 24%-55%]). The only significant adverse hematologic event was grade 3 neutropenia in 4 patients (9%). The most common adverse nonhematologic events were fatigue (84% of patients) and alopecia (84%), which were usually grade 1/2. Weekly docetaxel/carboplatin appears to be active and feasible as PST in patients with large breast tumors.

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Efficacy and safety of oxaliplatin and docetaxel in patients with locally advanced and metastatic non-small-cell lung cancer (NSCLC

Lung Cancer, 2006

Platinum-based doublets are recommended as treatment for advanced or metastatic non-small-cell lu... more Platinum-based doublets are recommended as treatment for advanced or metastatic non-small-cell lung cancer (NSCLC); however, chemotherapy must be tailored to limit side effects. A phase II study was conducted to evaluate the efficacy and safety of oxaliplatin combined with docetaxel for NSCLC. Patients with stage IIIB or IV, chemotherapy-naive NSCLC received docetaxel 70 mg/m(2), oxaliplatin 130 mg/m(2), and pegfilgrastim 6 mg every 21 days for up to six cycles. Primary endpoint was overall response rate (ORR), secondary endpoints were progression-free (PFS) and overall survival (OS), and safety. Twenty-nine patients were treated; 93% had stage IV disease and 28% had brain metastases. In 27 evaluable patients with follow-up, there were 10 partial responses for an ORR of 37% (90% confidence interval [CI], 22-55%). Median PFS was 4.6 months (95% CI, 2.6-6.5 months); 12-month PFS was 14.8% (95% CI, 3.4-34.0%). Median OS was 10.9 months (95% CI, 8.9-16.8 months); 12-month OS was 40% (95% CI, 19-61%) and 18-month OS was 16% (95% CI, 1-46%). In 29 treated patients, there were no unusual or unexpected adverse events. The most common grade 3 and 4 toxicities were anemia (14% of patients) and hyperglycemia (10%); there were only two reports of neutropenia; both were grade 1 or 2. These phase II findings suggest that the combination of oxaliplatin and docetaxel is active and well tolerated, and should be further investigated as a feasible treatment alternative for patients with advanced or metastatic NSCLC.

A Phase II Trial of Split, Low-Dose Docetaxel and Low-Dose Capecitabine: A Tolerable and Efficacious Regimen in the First-Line Treatment of Patients with HER2/ neu –Negative Metastatic Breast Cancer

Clinical Breast Cancer, 2008

Successful therapeutic regimens in metastatic breast cancer (MBC) must balance efficacy and toler... more Successful therapeutic regimens in metastatic breast cancer (MBC) must balance efficacy and tolerability. Docetaxel/ capecitabine is an active and commonly used doublet in the treatment of MBC. A phase III clinical trial has proven that it increases response rates (RRs) and median survival compared Background: Successful therapeutic regimens in metastatic breast cancer (MBC) must balance efficacy and tolerability. Docetaxel/capecitabine is an active and commonly used doublet in this setting. Docetaxel upregulates thymidine phosphorylase and thus potentiates the antitumor effects of capecitabine. A schedule with split, low-dose docetaxel in combination with low-dose capecitabine could improve the therapeutic index of this regimen without compromising its clinical activity. Patients and Methods: Patients with previously untreated HER2/neu-negative MBC were eligible. Treatment consisted of docetaxel 25 mg/m 2 on days 1 and 8 in combination with capecitabine 750 mg/m 2 twice daily on days 1-14 of a 3-week cycle. Thirty-nine women were enrolled. Median age was 55 years (range, 36-75 years). Fourteen patients had triple-negative disease. Sites of metastasis were as follows: bone (n = 27); liver (n = 15); lung (n = 17); nonregional chest (n = 4); lymph nodes (n = 2); and skin (n = 1). Six patients had bone-only disease. All subjects had a performance status of 0/1. A total of 329 cycles were administered (median, 6; range, 1-50). Results: Of 37 patients who received study treatment, 32 had evaluable disease, 1 had a complete response, and 15 had a partial response (overall response rate was 50% in evaluable patients and 43% in the intent-to-treat analysis). Six patients had stable disease. The overall clinical benefit rate was 69% for patients with evaluable disease and 60% overall. Fifteen patients had disease that progressed or had been withdrawn from study at the time of first evaluation. With a median follow-up of 25 months, median time to treatment failure was 4.25 months (95% CI, 1.5-7 months), and median overall survival has not yet been reached. Toxicity was moderate: 15 patients (41%) had grade 3/4 adverse events. Conclusion: Split, low-dose docetaxel and low-dose capecitabine is an active combination in the first-line treatment of patients with MBC. Toxicity with this schedule was manageable, making it an attractive regimen for further study in combination with targeted agents.

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4 - Açao política na internet brasileira

O artigo analisa a produção acadêmica sobre as diversas formas de ação política na Internet brasi... more O artigo analisa a produção acadêmica sobre as diversas formas de ação política na Internet brasileira. A partir da conceituação de ação política e sua adaptação para a web, o texto mostra as diferentes formas de participação política criadas e desenvolvidas no novo ambiente informacional, destacando a Internet como uma arena pública e um mecanismo para mobilização civil.

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Non-passive transport of volatile organic compounds in the unsaturated zone

Advances in Water Resources, 2007