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Featured article: Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes

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Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2

Authors: Henri Schmidt, Minsi Zhang, Dimitar Chakarov, Vineet Bansal, Haralambos Mourelatos, Francisco J. Sánchez-Rivera, Scott W. Lowe, Andrea Ventura, Christina S. Leslie and Yuri Pritykin

Content type: Methodology 26 February 2025
Cross-species imputation and comparison of single-cell transcriptomic profiles

Authors: Ran Zhang, Mu Yang, Jacob Schreiber, Diana R. O’Day, James M. A. Turner, Jay Shendure, William Stafford Noble, Christine M. Disteche and Xinxian Deng

Content type: Method 26 February 2025
Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP

Authors: Zhuoyi Song, Bongmin Bae, Simon Schnabl, Fei Yuan, Thareendra De Zoysa, Maureen V. Akinyi, Charlotte A. Le Roux, Karine Choquet, Amanda J. Whipple and Eric L. Van Nostrand

Content type: Research 25 February 2025
Digital sequencing is improved by using structured unique molecular identifiers

Authors: Peter Micallef, Manuel Luna Santamaría, Mandy Escobar, Daniel Andersson, Tobias Österlund, Pia Mouhanna, Stefan Filges, Gustav Johansson, Henrik Fagman, Christoffer Vannas and Anders Ståhlberg

Content type: Method 25 February 2025
Batch correcting single-cell spatial transcriptomics count data with Crescendo improves visualization and detection of spatial gene patterns

Authors: Nghia Millard, Jonathan H. Chen, Mukta G. Palshikar, Karin Pelka, Maxwell Spurrell, Colles Price, Jiang He, Nir Hacohen, Soumya Raychaudhuri and Ilya Korsunsky

Content type: Method 25 February 2025

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A survey of best practices for RNA-seq data analysis

Authors: Ana Conesa, Pedro Madrigal, Sonia Tarazona, David Gomez-Cabrero, Alejandra Cervera, Andrew McPherson, Michał Wojciech Szcześniak, Daniel J. Gaffney, Laura L. Elo, Xuegong Zhang and Ali Mortazavi

Content type: Review 26 January 2016

The Erratum to this article has been published in Genome Biology 2016 17:181
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Authors: Michael I Love, Wolfgang Huber and Simon Anders

Content type: METHOD 5 December 2014
The Kardashian index: a measure of discrepant social media profile for scientists

Authors: Neil Hall

Content type: Comment 30 July 2014
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Authors: Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe and Frank Speleman

Content type: Research 18 June 2002
Differential expression analysis for sequence count data

Authors: Simon Anders and Wolfgang Huber

Content type: Method 27 October 2010

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Genome Biology

Featured Articles

Featured article: Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes

Featured article: A fully phased octoploid strawberry genome reveals the evolutionary dynamism of centromeric satellites

Latest Collections Open for Submissions

Articles

Genome-wide CRISPR guide RNA design and specificity analysis with GuideScan2

Cross-species imputation and comparison of single-cell transcriptomic profiles

Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP

Digital sequencing is improved by using structured unique molecular identifiers

Batch correcting single-cell spatial transcriptomics count data with Crescendo improves visualization and detection of spatial gene patterns

A survey of best practices for RNA-seq data analysis

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

The Kardashian index: a measure of discrepant social media profile for scientists

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

Differential expression analysis for sequence count data

Latest articles from Genome Medicine

The landcape of Helicobacter pylori-mediated DNA breaks links bacterial genotoxicity to its oncogenic potential

Correction: Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone

Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance

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