diff --git a/Lib/test/test_threading.py b/Lib/test/test_threading.py
index 2bbad2dcc9..c9b0b5eda6 100644
--- a/Lib/test/test_threading.py
+++ b/Lib/test/test_threading.py
@@ -1382,8 +1382,6 @@ def test__all__(self):
 
 
 class InterruptMainTests(unittest.TestCase):
-    # TODO: RUSTPYTHON
-    @unittest.expectedFailure
     def test_interrupt_main_subthread(self):
         # Calling start_new_thread with a function that executes interrupt_main
         # should raise KeyboardInterrupt upon completion.
@@ -1395,16 +1393,12 @@ def call_interrupt():
             t.join()
         t.join()
 
-    # TODO: RUSTPYTHON
-    @unittest.expectedFailure
     def test_interrupt_main_mainthread(self):
         # Make sure that if interrupt_main is called in main thread that
         # KeyboardInterrupt is raised instantly.
         with self.assertRaises(KeyboardInterrupt):
             _thread.interrupt_main()
 
-    # TODO: RUSTPYTHON
-    @unittest.expectedFailure
     def test_interrupt_main_noerror(self):
         handler = signal.getsignal(signal.SIGINT)
         try:
diff --git a/vm/src/signal.rs b/vm/src/signal.rs
index 2d46c18497..bca7963426 100644
--- a/vm/src/signal.rs
+++ b/vm/src/signal.rs
@@ -55,6 +55,33 @@ pub(crate) fn set_triggered() {
     ANY_TRIGGERED.store(true, Ordering::Release);
 }
 
+pub fn assert_in_range(signum: i32, vm: &VirtualMachine) -> PyResult<()> {
+    if (1..NSIG as i32).contains(&signum) {
+        Ok(())
+    } else {
+        Err(vm.new_value_error("signal number out of range".to_owned()))
+    }
+}
+
+/// Similar to `PyErr_SetInterruptEx` in CPython
+///
+/// Missing signal handler for the given signal number is silently ignored.
+#[allow(dead_code)]
+#[cfg(not(target_arch = "wasm32"))]
+pub fn set_interrupt_ex(signum: i32, vm: &VirtualMachine) -> PyResult<()> {
+    use crate::stdlib::signal::_signal::{run_signal, SIG_DFL, SIG_IGN};
+    assert_in_range(signum, vm)?;
+
+    match signum as usize {
+        SIG_DFL | SIG_IGN => Ok(()),
+        _ => {
+            // interrupt the main thread with given signal number
+            run_signal(signum);
+            Ok(())
+        }
+    }
+}
+
 pub type UserSignal = Box<dyn FnOnce(&VirtualMachine) -> PyResult<()> + Send>;
 
 #[derive(Clone, Debug)]
diff --git a/vm/src/stdlib/signal.rs b/vm/src/stdlib/signal.rs
index 6212ab3e26..173dee28c3 100644
--- a/vm/src/stdlib/signal.rs
+++ b/vm/src/stdlib/signal.rs
@@ -33,23 +33,23 @@ pub(crate) mod _signal {
     }
 
     #[cfg(unix)]
-    use nix::unistd::alarm as sig_alarm;
+    pub use nix::unistd::alarm as sig_alarm;
 
     #[cfg(not(windows))]
-    use libc::SIG_ERR;
+    pub use libc::SIG_ERR;
 
     #[cfg(not(windows))]
     #[pyattr]
-    use libc::{SIG_DFL, SIG_IGN};
+    pub use libc::{SIG_DFL, SIG_IGN};
 
     #[cfg(windows)]
     #[pyattr]
-    const SIG_DFL: libc::sighandler_t = 0;
+    pub const SIG_DFL: libc::sighandler_t = 0;
     #[cfg(windows)]
     #[pyattr]
-    const SIG_IGN: libc::sighandler_t = 1;
+    pub const SIG_IGN: libc::sighandler_t = 1;
     #[cfg(windows)]
-    const SIG_ERR: libc::sighandler_t = !0;
+    pub const SIG_ERR: libc::sighandler_t = !0;
 
     #[cfg(all(unix, not(target_os = "redox")))]
     extern "C" {
@@ -60,7 +60,7 @@ pub(crate) mod _signal {
     use crate::signal::NSIG;
 
     #[pyattr]
-    use libc::{SIGABRT, SIGFPE, SIGILL, SIGINT, SIGSEGV, SIGTERM};
+    pub use libc::{SIGABRT, SIGFPE, SIGILL, SIGINT, SIGSEGV, SIGTERM};
 
     #[cfg(unix)]
     #[pyattr]
@@ -112,7 +112,7 @@ pub(crate) mod _signal {
         handler: PyObjectRef,
         vm: &VirtualMachine,
     ) -> PyResult<Option<PyObjectRef>> {
-        assert_in_range(signalnum, vm)?;
+        signal::assert_in_range(signalnum, vm)?;
         let signal_handlers = vm
             .signal_handlers
             .as_deref()
@@ -148,7 +148,7 @@ pub(crate) mod _signal {
 
     #[pyfunction]
     fn getsignal(signalnum: i32, vm: &VirtualMachine) -> PyResult {
-        assert_in_range(signalnum, vm)?;
+        signal::assert_in_range(signalnum, vm)?;
         let signal_handlers = vm
             .signal_handlers
             .as_deref()
@@ -246,7 +246,7 @@ pub(crate) mod _signal {
     #[cfg(all(unix, not(target_os = "redox")))]
     #[pyfunction(name = "siginterrupt")]
     fn py_siginterrupt(signum: i32, flag: i32, vm: &VirtualMachine) -> PyResult<()> {
-        assert_in_range(signum, vm)?;
+        signal::assert_in_range(signum, vm)?;
         let res = unsafe { siginterrupt(signum, flag) };
         if res < 0 {
             Err(crate::stdlib::os::errno_err(vm))
@@ -255,7 +255,7 @@ pub(crate) mod _signal {
         }
     }
 
-    extern "C" fn run_signal(signum: i32) {
+    pub extern "C" fn run_signal(signum: i32) {
         signal::TRIGGERS[signum as usize].store(true, Ordering::Relaxed);
         signal::set_triggered();
         let wakeup_fd = WAKEUP.load(Ordering::Relaxed);
@@ -271,12 +271,4 @@ pub(crate) mod _signal {
             // TODO: handle _res < 1, support warn_on_full_buffer
         }
     }
-
-    fn assert_in_range(signum: i32, vm: &VirtualMachine) -> PyResult<()> {
-        if (1..NSIG as i32).contains(&signum) {
-            Ok(())
-        } else {
-            Err(vm.new_value_error("signal number out of range".to_owned()))
-        }
-    }
 }
diff --git a/vm/src/stdlib/thread.rs b/vm/src/stdlib/thread.rs
index 95faea8095..576ba6a9a8 100644
--- a/vm/src/stdlib/thread.rs
+++ b/vm/src/stdlib/thread.rs
@@ -304,6 +304,12 @@ pub(crate) mod _thread {
         vm.state.thread_count.fetch_sub(1);
     }
 
+    #[cfg(not(target_arch = "wasm32"))]
+    #[pyfunction]
+    fn interrupt_main(signum: OptionalArg<i32>, vm: &VirtualMachine) -> PyResult<()> {
+        crate::signal::set_interrupt_ex(signum.unwrap_or(libc::SIGINT), vm)
+    }
+
     #[pyfunction]
     fn exit(vm: &VirtualMachine) -> PyResult {
         Err(vm.new_exception_empty(vm.ctx.exceptions.system_exit.to_owned()))