diff --git a/lib/tinyusb b/lib/tinyusb
index 6bba41045a422..8c1802e41d37c 160000
--- a/lib/tinyusb
+++ b/lib/tinyusb
@@ -1 +1 @@
-Subproject commit 6bba41045a4224abb68256dcf2fce893da47a743
+Subproject commit 8c1802e41d37c915334a19b859b24cb2a1b48ee5
diff --git a/ports/raspberrypi/lib/Pico-PIO-USB b/ports/raspberrypi/lib/Pico-PIO-USB
index 1862cc008e026..e0aba546813d8 160000
--- a/ports/raspberrypi/lib/Pico-PIO-USB
+++ b/ports/raspberrypi/lib/Pico-PIO-USB
@@ -1 +1 @@
-Subproject commit 1862cc008e026cbd07b97b28e29eafb5f38b35fb
+Subproject commit e0aba546813d89cb7f321bef3363bfba5f282e14
diff --git a/shared-bindings/usb/core/Device.c b/shared-bindings/usb/core/Device.c
index 28d178b748eae..683115a842102 100644
--- a/shared-bindings/usb/core/Device.c
+++ b/shared-bindings/usb/core/Device.c
@@ -39,6 +39,7 @@
 
 #include "py/objproperty.h"
 #include "shared-bindings/usb/core/Device.h"
+#include "shared-bindings/util.h"
 #include "py/runtime.h"
 
 //| class Device:
@@ -49,6 +50,12 @@
 //|         ...
 //|
 
+static void check_for_deinit(usb_core_device_obj_t *self) {
+    if (common_hal_usb_core_device_deinited(self)) {
+        raise_deinited_error();
+    }
+}
+
 //|     def __del__(self) -> None:
 //|         """Closes any resources used for this device."""
 //|         ...
@@ -64,6 +71,7 @@ static MP_DEFINE_CONST_FUN_OBJ_1(usb_core_device_deinit_obj, usb_core_device_dei
 //|     """The USB vendor ID of the device"""
 static mp_obj_t usb_core_device_obj_get_idVendor(mp_obj_t self_in) {
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(self_in);
+    check_for_deinit(self);
     return MP_OBJ_NEW_SMALL_INT(common_hal_usb_core_device_get_idVendor(self));
 }
 MP_DEFINE_CONST_FUN_OBJ_1(usb_core_device_get_idVendor_obj, usb_core_device_obj_get_idVendor);
@@ -75,6 +83,7 @@ MP_PROPERTY_GETTER(usb_core_device_idVendor_obj,
 //|     """The USB product ID of the device"""
 static mp_obj_t usb_core_device_obj_get_idProduct(mp_obj_t self_in) {
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(self_in);
+    check_for_deinit(self);
     return MP_OBJ_NEW_SMALL_INT(common_hal_usb_core_device_get_idProduct(self));
 }
 MP_DEFINE_CONST_FUN_OBJ_1(usb_core_device_get_idProduct_obj, usb_core_device_obj_get_idProduct);
@@ -86,6 +95,7 @@ MP_PROPERTY_GETTER(usb_core_device_idProduct_obj,
 //|     """The USB device's serial number string."""
 static mp_obj_t usb_core_device_obj_get_serial_number(mp_obj_t self_in) {
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(self_in);
+    check_for_deinit(self);
     return common_hal_usb_core_device_get_serial_number(self);
 }
 MP_DEFINE_CONST_FUN_OBJ_1(usb_core_device_get_serial_number_obj, usb_core_device_obj_get_serial_number);
@@ -97,6 +107,7 @@ MP_PROPERTY_GETTER(usb_core_device_serial_number_obj,
 //|     """The USB device's product string."""
 static mp_obj_t usb_core_device_obj_get_product(mp_obj_t self_in) {
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(self_in);
+    check_for_deinit(self);
     return common_hal_usb_core_device_get_product(self);
 }
 MP_DEFINE_CONST_FUN_OBJ_1(usb_core_device_get_product_obj, usb_core_device_obj_get_product);
@@ -109,6 +120,7 @@ MP_PROPERTY_GETTER(usb_core_device_product_obj,
 //|
 static mp_obj_t usb_core_device_obj_get_manufacturer(mp_obj_t self_in) {
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(self_in);
+    check_for_deinit(self);
     return common_hal_usb_core_device_get_manufacturer(self);
 }
 MP_DEFINE_CONST_FUN_OBJ_1(usb_core_device_get_manufacturer_obj, usb_core_device_obj_get_manufacturer);
@@ -121,6 +133,7 @@ MP_PROPERTY_GETTER(usb_core_device_manufacturer_obj,
 //|
 static mp_obj_t usb_core_device_obj_get_bus(mp_obj_t self_in) {
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(self_in);
+    check_for_deinit(self);
     return MP_OBJ_NEW_SMALL_INT(common_hal_usb_core_device_get_bus(self));
 }
 MP_DEFINE_CONST_FUN_OBJ_1(usb_core_device_get_bus_obj, usb_core_device_obj_get_bus);
@@ -134,6 +147,7 @@ MP_PROPERTY_GETTER(usb_core_device_bus_obj,
 //|
 static mp_obj_t usb_core_device_obj_get_port_numbers(mp_obj_t self_in) {
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(self_in);
+    check_for_deinit(self);
     return common_hal_usb_core_device_get_port_numbers(self);
 }
 MP_DEFINE_CONST_FUN_OBJ_1(usb_core_device_get_port_numbers_obj, usb_core_device_obj_get_port_numbers);
@@ -147,6 +161,7 @@ MP_PROPERTY_GETTER(usb_core_device_port_numbers_obj,
 //|
 static mp_obj_t usb_core_device_obj_get_speed(mp_obj_t self_in) {
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(self_in);
+    check_for_deinit(self);
     return MP_OBJ_NEW_SMALL_INT(common_hal_usb_core_device_get_speed(self));
 }
 MP_DEFINE_CONST_FUN_OBJ_1(usb_core_device_get_speed_obj, usb_core_device_obj_get_speed);
@@ -171,6 +186,7 @@ static mp_obj_t usb_core_device_set_configuration(size_t n_args, const mp_obj_t
         { MP_QSTR_configuration, MP_ARG_INT, {.u_int = 1} },
     };
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(pos_args[0]);
+    check_for_deinit(self);
     mp_arg_val_t args[MP_ARRAY_SIZE(allowed_args)];
     mp_arg_parse_all(n_args - 1, pos_args + 1, kw_args, MP_ARRAY_SIZE(allowed_args), allowed_args, args);
 
@@ -197,6 +213,7 @@ static mp_obj_t usb_core_device_write(size_t n_args, const mp_obj_t *pos_args, m
         { MP_QSTR_timeout, MP_ARG_INT, {.u_int = 0} },
     };
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(pos_args[0]);
+    check_for_deinit(self);
     mp_arg_val_t args[MP_ARRAY_SIZE(allowed_args)];
     mp_arg_parse_all(n_args - 1, pos_args + 1, kw_args, MP_ARRAY_SIZE(allowed_args), allowed_args, args);
 
@@ -228,6 +245,7 @@ static mp_obj_t usb_core_device_read(size_t n_args, const mp_obj_t *pos_args, mp
         { MP_QSTR_timeout, MP_ARG_INT, {.u_int = 0} },
     };
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(pos_args[0]);
+    check_for_deinit(self);
     mp_arg_val_t args[MP_ARRAY_SIZE(allowed_args)];
     mp_arg_parse_all(n_args - 1, pos_args + 1, kw_args, MP_ARRAY_SIZE(allowed_args), allowed_args, args);
 
@@ -277,6 +295,7 @@ static mp_obj_t usb_core_device_ctrl_transfer(size_t n_args, const mp_obj_t *pos
         { MP_QSTR_timeout, MP_ARG_INT, {.u_int = 0} },
     };
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(pos_args[0]);
+    check_for_deinit(self);
     mp_arg_val_t args[MP_ARRAY_SIZE(allowed_args)];
     mp_arg_parse_all(n_args - 1, pos_args + 1, kw_args, MP_ARRAY_SIZE(allowed_args), allowed_args, args);
 
@@ -310,6 +329,7 @@ MP_DEFINE_CONST_FUN_OBJ_KW(usb_core_device_ctrl_transfer_obj, 2, usb_core_device
 //|
 static mp_obj_t usb_core_device_is_kernel_driver_active(mp_obj_t self_in, mp_obj_t interface_in) {
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(self_in);
+    check_for_deinit(self);
     mp_int_t interface = mp_obj_get_int(interface_in);
     bool active = common_hal_usb_core_device_is_kernel_driver_active(self, interface);
     return mp_obj_new_bool(active);
@@ -327,6 +347,7 @@ MP_DEFINE_CONST_FUN_OBJ_2(usb_core_device_is_kernel_driver_active_obj, usb_core_
 //|
 static mp_obj_t usb_core_device_detach_kernel_driver(mp_obj_t self_in, mp_obj_t interface_in) {
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(self_in);
+    check_for_deinit(self);
     mp_int_t interface = mp_obj_get_int(interface_in);
     common_hal_usb_core_device_detach_kernel_driver(self, interface);
     return mp_const_none;
@@ -343,6 +364,7 @@ MP_DEFINE_CONST_FUN_OBJ_2(usb_core_device_detach_kernel_driver_obj, usb_core_dev
 //|
 static mp_obj_t usb_core_device_attach_kernel_driver(mp_obj_t self_in, mp_obj_t interface_in) {
     usb_core_device_obj_t *self = MP_OBJ_TO_PTR(self_in);
+    check_for_deinit(self);
     mp_int_t interface = mp_obj_get_int(interface_in);
     common_hal_usb_core_device_attach_kernel_driver(self, interface);
     return mp_const_none;
diff --git a/shared-bindings/usb/core/Device.h b/shared-bindings/usb/core/Device.h
index 7278ca297ede3..28c2cfbe19860 100644
--- a/shared-bindings/usb/core/Device.h
+++ b/shared-bindings/usb/core/Device.h
@@ -13,6 +13,7 @@
 extern const mp_obj_type_t usb_core_device_type;
 
 bool common_hal_usb_core_device_construct(usb_core_device_obj_t *self, uint8_t device_number);
+bool common_hal_usb_core_device_deinited(usb_core_device_obj_t *self);
 void common_hal_usb_core_device_deinit(usb_core_device_obj_t *self);
 uint16_t common_hal_usb_core_device_get_idVendor(usb_core_device_obj_t *self);
 uint16_t common_hal_usb_core_device_get_idProduct(usb_core_device_obj_t *self);
diff --git a/shared-module/usb/core/Device.c b/shared-module/usb/core/Device.c
index 10fdf63b1ed6f..0a52b925facf1 100644
--- a/shared-module/usb/core/Device.c
+++ b/shared-module/usb/core/Device.c
@@ -49,10 +49,22 @@ bool common_hal_usb_core_device_construct(usb_core_device_obj_t *self, uint8_t d
     return true;
 }
 
+bool common_hal_usb_core_device_deinited(usb_core_device_obj_t *self) {
+    return self->device_address == 0;
+}
+
 void common_hal_usb_core_device_deinit(usb_core_device_obj_t *self) {
-    // TODO: Close all of the endpoints we've opened. Some drivers store state
-    // for each open endpoint. If we don't close them, then we'll leak memory.
-    // Waiting for TinyUSB to add this.
+    if (common_hal_usb_core_device_deinited(self)) {
+        return;
+    }
+    size_t open_size = sizeof(self->open_endpoints);
+    for (size_t i = 0; i < open_size; i++) {
+        if (self->open_endpoints[i] != 0) {
+            tuh_edpt_close(self->device_address, self->open_endpoints[i]);
+            self->open_endpoints[i] = 0;
+        }
+    }
+    self->device_address = 0;
 }
 
 uint16_t common_hal_usb_core_device_get_idVendor(usb_core_device_obj_t *self) {