All supported Linuxes: - Debian 8+ - Ubuntu 14.04+ - Fedora 24+ - openSUSE 13.3+ CEF Python builds using sysroot and thus supports the same OSes as Google Chrome: https://support.google.com/chrome/a/answer/7100626?hl=en I've just tested cefpython v66.0 on Fedora 25 and it works out of the box.