diff --git a/rest_framework/serializers.py b/rest_framework/serializers.py
index 01f34298b4..279898d082 100644
--- a/rest_framework/serializers.py
+++ b/rest_framework/serializers.py
@@ -791,6 +791,8 @@ def raise_errors_on_nested_writes(method_name, serializer, validated_data):
     * Silently ignore the nested part of the update.
     * Automatically create a profile instance.
     """
+    ModelClass = serializer.Meta.model
+    model_field_info = model_meta.get_field_info(ModelClass)
 
     # Ensure we don't have a writable nested field. For example:
     #
@@ -800,6 +802,7 @@ def raise_errors_on_nested_writes(method_name, serializer, validated_data):
     assert not any(
         isinstance(field, BaseSerializer) and
         (field.source in validated_data) and
+        (field.source in model_field_info.relations) and
         isinstance(validated_data[field.source], (list, dict))
         for field in serializer._writable_fields
     ), (
@@ -818,9 +821,19 @@ def raise_errors_on_nested_writes(method_name, serializer, validated_data):
     # class UserSerializer(ModelSerializer):
     #     ...
     #     address = serializer.CharField('profile.address')
+    #
+    # Though, non-relational fields (e.g., JSONField) are acceptable. For example:
+    #
+    # class NonRelationalPersonModel(models.Model):
+    #     profile = JSONField()
+    #
+    # class UserSerializer(ModelSerializer):
+    #     ...
+    #     address = serializer.CharField('profile.address')
     assert not any(
         len(field.source_attrs) > 1 and
         (field.source_attrs[0] in validated_data) and
+        (field.source_attrs[0] in model_field_info.relations) and
         isinstance(validated_data[field.source_attrs[0]], (list, dict))
         for field in serializer._writable_fields
     ), (
diff --git a/tests/test_serializer_nested.py b/tests/test_serializer_nested.py
index ab30fad223..a614e05d13 100644
--- a/tests/test_serializer_nested.py
+++ b/tests/test_serializer_nested.py
@@ -4,6 +4,8 @@
 from django.test import TestCase
 
 from rest_framework import serializers
+from rest_framework.compat import postgres_fields
+from rest_framework.serializers import raise_errors_on_nested_writes
 
 
 class TestNestedSerializer:
@@ -302,3 +304,50 @@ class Meta:
             'serializer `tests.test_serializer_nested.DottedAddressSerializer`, '
             'or set `read_only=True` on dotted-source serializer fields.'
         )
+
+
+if postgres_fields:
+    class NonRelationalPersonModel(models.Model):
+        """Model declaring a postgres JSONField"""
+        data = postgres_fields.JSONField()
+
+
+@pytest.mark.skipif(not postgres_fields, reason='psycopg2 is not installed')
+class TestNestedNonRelationalFieldWrite:
+    """
+    Test that raise_errors_on_nested_writes does not raise `AssertionError` when the
+    model field is not a relation.
+    """
+
+    def test_nested_serializer_create_and_update(self):
+
+        class NonRelationalPersonDataSerializer(serializers.Serializer):
+            occupation = serializers.CharField()
+
+        class NonRelationalPersonSerializer(serializers.ModelSerializer):
+            data = NonRelationalPersonDataSerializer()
+
+            class Meta:
+                model = NonRelationalPersonModel
+                fields = ['data']
+
+        serializer = NonRelationalPersonSerializer(data={'data': {'occupation': 'developer'}})
+        assert serializer.is_valid()
+        assert serializer.validated_data == {'data': {'occupation': 'developer'}}
+        raise_errors_on_nested_writes('create', serializer, serializer.validated_data)
+        raise_errors_on_nested_writes('update', serializer, serializer.validated_data)
+
+    def test_dotted_source_field_create_and_update(self):
+
+        class DottedNonRelationalPersonSerializer(serializers.ModelSerializer):
+            occupation = serializers.CharField(source='data.occupation')
+
+            class Meta:
+                model = NonRelationalPersonModel
+                fields = ['occupation']
+
+        serializer = DottedNonRelationalPersonSerializer(data={'occupation': 'developer'})
+        assert serializer.is_valid()
+        assert serializer.validated_data == {'data': {'occupation': 'developer'}}
+        raise_errors_on_nested_writes('create', serializer, serializer.validated_data)
+        raise_errors_on_nested_writes('update', serializer, serializer.validated_data)