diff --git a/setup.py b/setup.py
index e16feb2..53e2727 100644
--- a/setup.py
+++ b/setup.py
@@ -29,8 +29,8 @@
     # Until this issue is closed
     # https://github.com/googleapis/google-cloud-python/issues/10566
     "google-api-core[grpc] >= 1.31.5, <3.0.0dev,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.0",
-    "proto-plus >= 1.15.0, <2.0.0dev",
-    "protobuf >= 3.19.0, <4.0.0dev",
+    "proto-plus >= 1.22.0, <2.0.0dev",
+    "protobuf >= 3.19.0, <5.0.0dev",
 ]
 
 package_root = os.path.abspath(os.path.dirname(__file__))
diff --git a/testing/constraints-3.7.txt b/testing/constraints-3.7.txt
index 786e637..5a2f012 100644
--- a/testing/constraints-3.7.txt
+++ b/testing/constraints-3.7.txt
@@ -5,5 +5,5 @@
 # e.g., if setup.py has "google-cloud-foo >= 1.14.0, < 2.0.0dev",
 # Then this file should have google-cloud-foo==1.14.0
 google-api-core==1.31.5
-proto-plus==1.15.0
+proto-plus==1.22.0
 protobuf==3.19.0