diff --git a/localstack-core/localstack/utils/container_utils/container_client.py b/localstack-core/localstack/utils/container_utils/container_client.py
index 075b339d95731..7e1b2b0c0cdc2 100644
--- a/localstack-core/localstack/utils/container_utils/container_client.py
+++ b/localstack-core/localstack/utils/container_utils/container_client.py
@@ -450,7 +450,7 @@ class ContainerConfiguration:
     volumes: VolumeMappings = dataclasses.field(default_factory=VolumeMappings)
     ports: PortMappings = dataclasses.field(default_factory=PortMappings)
     exposed_ports: List[str] = dataclasses.field(default_factory=list)
-    entrypoint: Optional[str] = None
+    entrypoint: Optional[Union[List[str], str]] = None
     additional_flags: Optional[str] = None
     command: Optional[List[str]] = None
     env_vars: Dict[str, str] = dataclasses.field(default_factory=dict)
@@ -861,7 +861,7 @@ def create_container(
         image_name: str,
         *,
         name: Optional[str] = None,
-        entrypoint: Optional[str] = None,
+        entrypoint: Optional[Union[List[str], str]] = None,
         remove: bool = False,
         interactive: bool = False,
         tty: bool = False,
diff --git a/localstack-core/localstack/utils/container_utils/docker_cmd_client.py b/localstack-core/localstack/utils/container_utils/docker_cmd_client.py
index 440c8593c7f47..360e9bdbe3434 100644
--- a/localstack-core/localstack/utils/container_utils/docker_cmd_client.py
+++ b/localstack-core/localstack/utils/container_utils/docker_cmd_client.py
@@ -714,7 +714,7 @@ def _build_run_create_cmd(
         image_name: str,
         *,
         name: Optional[str] = None,
-        entrypoint: Optional[str] = None,
+        entrypoint: Optional[Union[List[str], str]] = None,
         remove: bool = False,
         interactive: bool = False,
         tty: bool = False,
@@ -746,7 +746,10 @@ def _build_run_create_cmd(
         if name:
             cmd += ["--name", name]
         if entrypoint is not None:  # empty string entrypoint can be intentional
-            cmd += ["--entrypoint", entrypoint]
+            if isinstance(entrypoint, str):
+                cmd += ["--entrypoint", entrypoint]
+            else:
+                cmd += ["--entrypoint", shlex.join(entrypoint)]
         if privileged:
             cmd += ["--privileged"]
         if volumes:
diff --git a/localstack-core/localstack/utils/container_utils/docker_sdk_client.py b/localstack-core/localstack/utils/container_utils/docker_sdk_client.py
index e38cb2e203117..29ecd0a4424ec 100644
--- a/localstack-core/localstack/utils/container_utils/docker_sdk_client.py
+++ b/localstack-core/localstack/utils/container_utils/docker_sdk_client.py
@@ -606,7 +606,7 @@ def create_container(
         image_name: str,
         *,
         name: Optional[str] = None,
-        entrypoint: Optional[str] = None,
+        entrypoint: Optional[Union[List[str], str]] = None,
         remove: bool = False,
         interactive: bool = False,
         tty: bool = False,
diff --git a/tests/integration/docker_utils/test_docker.py b/tests/integration/docker_utils/test_docker.py
index 001ca7595eb18..a2b785e881b5a 100644
--- a/tests/integration/docker_utils/test_docker.py
+++ b/tests/integration/docker_utils/test_docker.py
@@ -6,7 +6,7 @@
 import re
 import textwrap
 import time
-from typing import NamedTuple, Type
+from typing import Callable, NamedTuple, Type
 
 import pytest
 from docker.models.containers import Container
@@ -85,7 +85,7 @@ def create_container(docker_client: ContainerClient, create_network):
     """
     containers = []
 
-    def _create_container(image_name: str, **kwargs):
+    def _create_container(image_name: str, **kwargs) -> ContainerInfo:
         kwargs["name"] = kwargs.get("name", _random_container_name())
         cid = docker_client.create_container(image_name, **kwargs)
         cid = cid.strip()
@@ -187,6 +187,28 @@ def test_create_container_remove_removes_container(
         # it takes a while for it to be removed
         assert "foobar" in output
 
+    @pytest.mark.parametrize(
+        "entrypoint",
+        [
+            "echo",
+            ["echo"],
+        ],
+    )
+    def test_set_container_entrypoint(
+        self,
+        docker_client: ContainerClient,
+        create_container: Callable[..., ContainerInfo],
+        entrypoint: list[str] | str,
+    ):
+        info = create_container("alpine", entrypoint=entrypoint, command=["true"])
+        assert 1 == len(docker_client.list_containers(f"id={info.container_id}"))
+
+        # start the container
+        output, _ = docker_client.start_container(info.container_id, attach=True)
+        output = to_str(output).strip()
+
+        assert output == "true"
+
     @markers.skip_offline
     def test_create_container_non_existing_image(self, docker_client: ContainerClient):
         with pytest.raises(NoSuchImage):