diff --git a/lib/matplotlib/figure.py b/lib/matplotlib/figure.py
index 15271c9c4020..ed6866479a69 100644
--- a/lib/matplotlib/figure.py
+++ b/lib/matplotlib/figure.py
@@ -1425,6 +1425,8 @@ def clf(self, keep_observers=False):
         if not keep_observers:
             self._axobservers = []
         self._suptitle = None
+        if self.get_constrained_layout():
+            layoutbox.nonetree(self._layoutbox)
         self.stale = True
 
     def clear(self, keep_observers=False):