diff --git a/.github/workflows/tests.yml b/.github/workflows/tests.yml
index 13ae3c8d3322..e803b7835508 100644
--- a/.github/workflows/tests.yml
+++ b/.github/workflows/tests.yml
@@ -8,6 +8,9 @@ on:
   pull_request:
     branches-ignore:
       - v[0-9]+.[0-9]+.[0-9x]+-doc
+  schedule:
+    # 3:47 UTC on Saturdays
+    - cron: "47 3 * * 6"
 
 env:
   NO_AT_BRIDGE: 1  # Necessary for GTK3 interactive test.
@@ -209,6 +212,20 @@ jobs:
             echo 'wxPython is available' ||
             echo 'wxPython is not available'
 
+      - name: Install the nightly dependencies
+        # Only install the nightly dependencies during the scheduled event
+        if: ${{ github.event_name == 'schedule' && matrix.name-suffix != '(Minimum Versions)' }}
+        run: |
+          python -m pip install -i https://pypi.anaconda.org/scipy-wheels-nightly/simple --upgrade numpy pandas
+
+          # Turn all warnings to errors, except ignore the distutils deprecations and the find_spec warning
+          cat >> pytest.ini << EOF
+          filterwarnings =
+              error
+              ignore:.*distutils:DeprecationWarning
+              ignore:DynamicImporter.find_spec\(\) not found; falling back to find_module\(\):ImportWarning
+          EOF
+
       - name: Install Matplotlib
         run: |
           ccache -s
@@ -266,3 +283,18 @@ jobs:
         with:
           name: "${{ matrix.python-version }} ${{ matrix.os }} ${{ matrix.name-suffix }} result images"
           path: ./result_images
+
+      - name: Create issue on failure
+        uses: imjohnbo/issue-bot@v3
+        if: ${{ failure() && github.event_name == 'schedule' }}
+        with:
+          title: "[TST] Upcoming dependency test failures"
+          body: |
+            The weekly build with nightly wheels from numpy and pandas
+            has failed. Check the logs for any updates that need to be
+            made in matplotlib.
+
+          pinned: false
+          close-previous: false
+        env:
+          GITHUB_TOKEN: ${{ secrets.GITHUB_TOKEN }}
\ No newline at end of file
diff --git a/lib/matplotlib/tests/test_axes.py b/lib/matplotlib/tests/test_axes.py
index 81b1b09ddd51..26579aaf8671 100644
--- a/lib/matplotlib/tests/test_axes.py
+++ b/lib/matplotlib/tests/test_axes.py
@@ -3438,6 +3438,8 @@ def test_errorbar():
     ax.errorbar(x, y, yerr=[yerr_lower, 2*yerr], xerr=xerr,
                 fmt='o', ecolor='g', capthick=2)
     ax.set_title('Mixed sym., log y')
+    # Force limits due to floating point slop potentially expanding the range
+    ax.set_ylim(1e-2, 1e1)
 
     fig.suptitle('Variable errorbars')
 
diff --git a/lib/matplotlib/tests/test_colors.py b/lib/matplotlib/tests/test_colors.py
index 0db62f82b64e..e72b9d7a8d28 100644
--- a/lib/matplotlib/tests/test_colors.py
+++ b/lib/matplotlib/tests/test_colors.py
@@ -568,14 +568,15 @@ def test_Normalize():
     # Don't lose precision on longdoubles (float128 on Linux):
     # for array inputs...
     vals = np.array([1.2345678901, 9.8765432109], dtype=np.longdouble)
-    norm = mcolors.Normalize(vals.min(), vals.max())
-    assert_array_equal(np.asarray(norm(vals)), [0, 1])
+    norm = mcolors.Normalize(vals[0], vals[1])
+    assert norm(vals).dtype == np.longdouble
+    assert_array_equal(norm(vals), [0, 1])
     # and for scalar ones.
     eps = np.finfo(np.longdouble).resolution
     norm = plt.Normalize(1, 1 + 100 * eps)
     # This returns exactly 0.5 when longdouble is extended precision (80-bit),
     # but only a value close to it when it is quadruple precision (128-bit).
-    assert 0 < norm(1 + 50 * eps) < 1
+    np.testing.assert_array_almost_equal_nulp(norm(1 + 50 * eps), 0.5)
 
 
 def test_FuncNorm():